Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial
Purpose: To investigate the effect of topical Polyvinylpyrrolidone-iodine (PVP-I) 0.6% on the clinical course of adenoviral keratoconjunctivitis compared with PVP-I 1% and artificial tears. Methods: We prospectively enrolled all patients over 18 years of age with a polymerase chain reaction (PCR)-co...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-08-01
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| Series: | Journal of Current Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/joco.joco_251_23 |
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| author | Ali Makateb Mahdi Soleymanzadeh Saeed Soleiman-Meigooni Ali Asgari Mohammad Reza Etemadi Amir Reza Mafi Nader Mohammadi |
| author_facet | Ali Makateb Mahdi Soleymanzadeh Saeed Soleiman-Meigooni Ali Asgari Mohammad Reza Etemadi Amir Reza Mafi Nader Mohammadi |
| author_sort | Ali Makateb |
| collection | DOAJ |
| description | Purpose:
To investigate the effect of topical Polyvinylpyrrolidone-iodine (PVP-I) 0.6% on the clinical course of adenoviral keratoconjunctivitis compared with PVP-I 1% and artificial tears.
Methods:
We prospectively enrolled all patients over 18 years of age with a polymerase chain reaction (PCR)-confirmed diagnosis of adenoviral keratoconjunctivitis who presented to the hospital between November 2022 and June 2023. Patients were randomized into 3 groups: artificial tears (control), PVP-I 1%, and PVP-I 0.6% eye drops, 4 times daily for 5 days. Clinical signs at presentation and at 6 follow-up visits during the 1st 3 weeks of the acute phase were recorded. Patients were also followed up at 1 and 3 months.
Results:
Ninety-four patients completed the study, of which 30, 31, and 33 were in the control, PVP-I 1%, and PVP-I 0.6% groups, respectively. The mean age of the patients was 37.2 years (interquartile range: 25-46). The PCR result was positive in 75.6% of patients with the clinical suspicion. PVP-I, regardless of the concentration, was superior to the artificial tears in terms of time to resolution of lid swelling, discharge, and incidence of subsequent subepithelial infiltrates (P < 0.05). However, a concentration of 0.6% was equivalent to 1%. No significant adverse events were reported in any group.
Conclusions:
The PVP-I 0.6% topical drops are safe and well tolerated in patients with acute adenoviral keratoconjunctivitis. It can be substituted for the 1% solution as it has comparable effects in improving the clinical course and reducing subsequent complications. |
| format | Article |
| id | doaj-art-6e163b99de71482aa3060966d64337c8 |
| institution | OA Journals |
| issn | 2452-2325 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Ophthalmology |
| spelling | doaj-art-6e163b99de71482aa3060966d64337c82025-08-20T02:09:48ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252024-08-0135433734410.4103/joco.joco_251_23Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical TrialAli MakatebMahdi SoleymanzadehSaeed Soleiman-MeigooniAli AsgariMohammad Reza EtemadiAmir Reza MafiNader MohammadiPurpose: To investigate the effect of topical Polyvinylpyrrolidone-iodine (PVP-I) 0.6% on the clinical course of adenoviral keratoconjunctivitis compared with PVP-I 1% and artificial tears. Methods: We prospectively enrolled all patients over 18 years of age with a polymerase chain reaction (PCR)-confirmed diagnosis of adenoviral keratoconjunctivitis who presented to the hospital between November 2022 and June 2023. Patients were randomized into 3 groups: artificial tears (control), PVP-I 1%, and PVP-I 0.6% eye drops, 4 times daily for 5 days. Clinical signs at presentation and at 6 follow-up visits during the 1st 3 weeks of the acute phase were recorded. Patients were also followed up at 1 and 3 months. Results: Ninety-four patients completed the study, of which 30, 31, and 33 were in the control, PVP-I 1%, and PVP-I 0.6% groups, respectively. The mean age of the patients was 37.2 years (interquartile range: 25-46). The PCR result was positive in 75.6% of patients with the clinical suspicion. PVP-I, regardless of the concentration, was superior to the artificial tears in terms of time to resolution of lid swelling, discharge, and incidence of subsequent subepithelial infiltrates (P < 0.05). However, a concentration of 0.6% was equivalent to 1%. No significant adverse events were reported in any group. Conclusions: The PVP-I 0.6% topical drops are safe and well tolerated in patients with acute adenoviral keratoconjunctivitis. It can be substituted for the 1% solution as it has comparable effects in improving the clinical course and reducing subsequent complications.https://journals.lww.com/10.4103/joco.joco_251_23antiviral agentsepidemic keratoconjunctivitishuman adenoviruspovidone-iodinesubepithelial infiltrates |
| spellingShingle | Ali Makateb Mahdi Soleymanzadeh Saeed Soleiman-Meigooni Ali Asgari Mohammad Reza Etemadi Amir Reza Mafi Nader Mohammadi Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial Journal of Current Ophthalmology antiviral agents epidemic keratoconjunctivitis human adenovirus povidone-iodine subepithelial infiltrates |
| title | Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial |
| title_full | Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial |
| title_fullStr | Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial |
| title_full_unstemmed | Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial |
| title_short | Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial |
| title_sort | comparison between the efficacy and tolerability of polyvinylpyrrolidone iodine eye drops 0 6 and 1 in adenoviral keratoconjunctivitis a randomized clinical trial |
| topic | antiviral agents epidemic keratoconjunctivitis human adenovirus povidone-iodine subepithelial infiltrates |
| url | https://journals.lww.com/10.4103/joco.joco_251_23 |
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