The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.

The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis.

Growing evidence supports the importance of ubiquitin ligases in the pathogenesis of muscular disorders, although underlying mechanisms remain largely elusive. Here we show that the expression of RNF5 (aka RMA1), an ER-anchored RING finger E3 ligase implicated in muscle organization and in recogniti...

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Main Authors: Agnès Delaunay, Kenneth D Bromberg, Yukiko Hayashi, Massimiliano Mirabella, Denise Burch, Brian Kirkwood, Carlo Serra, May C Malicdan, Andrew P Mizisin, Roberta Morosetti, Aldobrando Broccolini, Ling T Guo, Stephen N Jones, Sergio A Lira, Pier Lorenzo Puri, G Diane Shelton, Ze'ev Ronai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001609&type=printable
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