Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.

Mutations in GBA (glucosylceramidase beta), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative disorders Parkinson's disease (PD) and Lewy body dementia. Recent work has suggested that neuroinflammation may be an import...

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Bibliographic Details
Main Authors: Evelyn S Vincow, Ruth E Thomas, Gillian Milstein, Gautam Pareek, Theo K Bammler, James MacDonald, Leo J Pallanck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011105
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