Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis
Psoriasis is an immune-mediated skin condition. There are many therapeutic options for its treatment; however, none of them is completely effective. Tapinarof is a promising new active substance; it was recently approved by the FDA for the treatment of psoriasis. The aim of our study was to prepare...
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2024-10-01
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| author | Barbara Balogh Ágota Pető Ádám Haimhoffer Dávid Sinka Dóra Kósa Pálma Fehér Zoltán Ujhelyi Monica Argenziano Roberta Cavalli Ildikó Bácskay |
| author_facet | Barbara Balogh Ágota Pető Ádám Haimhoffer Dávid Sinka Dóra Kósa Pálma Fehér Zoltán Ujhelyi Monica Argenziano Roberta Cavalli Ildikó Bácskay |
| author_sort | Barbara Balogh |
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| description | Psoriasis is an immune-mediated skin condition. There are many therapeutic options for its treatment; however, none of them is completely effective. Tapinarof is a promising new active substance; it was recently approved by the FDA for the treatment of psoriasis. The aim of our study was to prepare topical nanoformulations of the active substance to improve its bioavailability and therapeutic effect. The biocompatibility investigation of the formulations was carried out by MTT assay, and the size distribution of the preparations was investigated by DLS. In parallel, the rheological properties and the texture were examined, and the in vitro release of tapinarof was assessed by the Franz diffusion method. An in vitro wound healing assay was also carried out to study the drug’s properties. Our results show that the preparations were safe on HaCaT cells. The particle size of the formulations was proven to be in the nanoscale range. In the in vitro release studies, nanogel II. showed greater release of the active substance. According to the wound healing assay, incorporation of the drug into nanoformulations increases the antiproliferative and antimigration activity of the drug. Overall, nanoformulations of tapinarof were successfully prepared, and our results suggest that they can be a useful addition to the current therapeutic practice of psoriasis. |
| format | Article |
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| institution | OA Journals |
| issn | 2310-2861 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Gels |
| spelling | doaj-art-6e0529bc7ace429985dddbff2562f6852025-08-20T01:53:44ZengMDPI AGGels2310-28612024-10-01101167510.3390/gels10110675Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of PsoriasisBarbara Balogh0Ágota Pető1Ádám Haimhoffer2Dávid Sinka3Dóra Kósa4Pálma Fehér5Zoltán Ujhelyi6Monica Argenziano7Roberta Cavalli8Ildikó Bácskay9Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, ItalyDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, ItalyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, HungaryPsoriasis is an immune-mediated skin condition. There are many therapeutic options for its treatment; however, none of them is completely effective. Tapinarof is a promising new active substance; it was recently approved by the FDA for the treatment of psoriasis. The aim of our study was to prepare topical nanoformulations of the active substance to improve its bioavailability and therapeutic effect. The biocompatibility investigation of the formulations was carried out by MTT assay, and the size distribution of the preparations was investigated by DLS. In parallel, the rheological properties and the texture were examined, and the in vitro release of tapinarof was assessed by the Franz diffusion method. An in vitro wound healing assay was also carried out to study the drug’s properties. Our results show that the preparations were safe on HaCaT cells. The particle size of the formulations was proven to be in the nanoscale range. In the in vitro release studies, nanogel II. showed greater release of the active substance. According to the wound healing assay, incorporation of the drug into nanoformulations increases the antiproliferative and antimigration activity of the drug. Overall, nanoformulations of tapinarof were successfully prepared, and our results suggest that they can be a useful addition to the current therapeutic practice of psoriasis.https://www.mdpi.com/2310-2861/10/11/675tapinarofnanogelspsoriasisSNEDDSwound healing |
| spellingShingle | Barbara Balogh Ágota Pető Ádám Haimhoffer Dávid Sinka Dóra Kósa Pálma Fehér Zoltán Ujhelyi Monica Argenziano Roberta Cavalli Ildikó Bácskay Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis Gels tapinarof nanogels psoriasis SNEDDS wound healing |
| title | Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis |
| title_full | Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis |
| title_fullStr | Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis |
| title_full_unstemmed | Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis |
| title_short | Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis |
| title_sort | formulation and evaluation of different nanogels of tapinarof for treatment of psoriasis |
| topic | tapinarof nanogels psoriasis SNEDDS wound healing |
| url | https://www.mdpi.com/2310-2861/10/11/675 |
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