Protein Prenylation in Plants: Mechanisms and Functional Implications
Protein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins. This modification plays a significant role in determining protein localization, facilitating protein–protein inter...
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MDPI AG
2025-06-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/14/12/1759 |
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| author | Chang Tian Quan Wang |
| author_facet | Chang Tian Quan Wang |
| author_sort | Chang Tian |
| collection | DOAJ |
| description | Protein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins. This modification plays a significant role in determining protein localization, facilitating protein–protein interactions, and ultimately influencing protein function within the cellular context. Prenylation is a conserved process observed across various kingdoms of life, including plants, animals, fungi, and protists. This review aims to consolidate existing knowledge regarding the mechanisms underlying protein prenylation, encompassing the biosynthetic pathways of isoprenoids in plants and the processing involved in the prenylation modification. Furthermore, it highlights the implications of alterations in protein prenylation on plant development, signaling pathways, and stress responses. The review also addresses the similarities in modification mechanisms between plants and animals, as well as the diversity of their functional implications. Finally, it outlines prospective research directions of the plant prenylation mechanisms and the potential applications in the field of biotechnology. |
| format | Article |
| id | doaj-art-6e02ba90b6f54270b87a73c007723e7e |
| institution | OA Journals |
| issn | 2223-7747 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj-art-6e02ba90b6f54270b87a73c007723e7e2025-08-20T02:21:53ZengMDPI AGPlants2223-77472025-06-011412175910.3390/plants14121759Protein Prenylation in Plants: Mechanisms and Functional ImplicationsChang Tian0Quan Wang1Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, ChinaShenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, ChinaProtein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins. This modification plays a significant role in determining protein localization, facilitating protein–protein interactions, and ultimately influencing protein function within the cellular context. Prenylation is a conserved process observed across various kingdoms of life, including plants, animals, fungi, and protists. This review aims to consolidate existing knowledge regarding the mechanisms underlying protein prenylation, encompassing the biosynthetic pathways of isoprenoids in plants and the processing involved in the prenylation modification. Furthermore, it highlights the implications of alterations in protein prenylation on plant development, signaling pathways, and stress responses. The review also addresses the similarities in modification mechanisms between plants and animals, as well as the diversity of their functional implications. Finally, it outlines prospective research directions of the plant prenylation mechanisms and the potential applications in the field of biotechnology.https://www.mdpi.com/2223-7747/14/12/1759protein prenylationfarnesyltransferasegeranylgeranyltransferasemodification mechanismfunctional implications |
| spellingShingle | Chang Tian Quan Wang Protein Prenylation in Plants: Mechanisms and Functional Implications Plants protein prenylation farnesyltransferase geranylgeranyltransferase modification mechanism functional implications |
| title | Protein Prenylation in Plants: Mechanisms and Functional Implications |
| title_full | Protein Prenylation in Plants: Mechanisms and Functional Implications |
| title_fullStr | Protein Prenylation in Plants: Mechanisms and Functional Implications |
| title_full_unstemmed | Protein Prenylation in Plants: Mechanisms and Functional Implications |
| title_short | Protein Prenylation in Plants: Mechanisms and Functional Implications |
| title_sort | protein prenylation in plants mechanisms and functional implications |
| topic | protein prenylation farnesyltransferase geranylgeranyltransferase modification mechanism functional implications |
| url | https://www.mdpi.com/2223-7747/14/12/1759 |
| work_keys_str_mv | AT changtian proteinprenylationinplantsmechanismsandfunctionalimplications AT quanwang proteinprenylationinplantsmechanismsandfunctionalimplications |