Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting
Background: Abnormal uterine bleeding is a common sign which cover various conditions e/o pathologies. Different approaches are used to evaluate this condition. The aim of this study was to investigate the validity of Pipelle biopsy for endometrial sampling in Kazakhstani women with abnormal uterine...
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| Format: | Article |
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IMR Press
2021-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.2510 |
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| author | Gulzhanat Aimagambetova Aiym Kaiyrlykyzy Gauri Bapayeva Talshyn Ukybassova Kamila Kenbayeva Bakytkali Ibrayimov Alla Lyasova Giulio Bonaldo Giovanni Buzzaccarini Marco Noventa Antonio Simone Laganà Milan Terzic |
| author_facet | Gulzhanat Aimagambetova Aiym Kaiyrlykyzy Gauri Bapayeva Talshyn Ukybassova Kamila Kenbayeva Bakytkali Ibrayimov Alla Lyasova Giulio Bonaldo Giovanni Buzzaccarini Marco Noventa Antonio Simone Laganà Milan Terzic |
| author_sort | Gulzhanat Aimagambetova |
| collection | DOAJ |
| description | Background: Abnormal uterine bleeding is a common sign which cover various conditions e/o pathologies. Different approaches are used to evaluate this condition. The aim of this study was to investigate the validity of Pipelle biopsy for endometrial sampling in Kazakhstani women with abnormal uterine bleeding. For this reason, we carried out a prospective study of 120 patients who underwent endometrial sampling due to abnormal uterine bleeding in a tertiary hospital setting in Kazakhstan. Methods: Statistics included descriptive analysis to evaluate the frequency of various endometrial conditions. The validity of Pipelle biopsy sampling was calculated by estimating sensitivity, specificity, accuracy, and positive and negative predictive values. For the Pipelle sampling validity assessment, we analyzed 120 samples, as 21 patients with insufficient samples were excluded. Results: Overall, concordance in histopathologic results was 92.93%. Pipelle sampling identified two cases of adenocarcinoma in our group. Moreover, endometrial hyperplasia was detected with 71.43% sensitivity, 98.82% specificity, PPV of 90.91% and NPV of 95.45%. However, the Pipelle reliability was low in cases of endometrial polyps. In conclusion, the Pipelle method was found to be valid for the diagnosis of endometrial hyperplasia and adenocarcinoma with high SN, SP, PPV and NPV. Conclusions: The Pipelle technique for evaluation of abnormal uterine bleeding in the Kazakhstani health care setting is a useful method with the highest efficacy in ruling out endometrial hyperplasia and diagnosing adenocarcinoma. If endometrial polyp was suspected under ultrasound scan in patients with abnormal uterine bleeding, physicians should consider other tools for endometrial sampling. |
| format | Article |
| id | doaj-art-6dfd2ee35a594410b02116614c2faced |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-6dfd2ee35a594410b02116614c2faced2025-08-20T01:57:03ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-06-0148367067510.31083/j.ceog.2021.03.2510S0390-6663(21)00176-7Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare settingGulzhanat Aimagambetova0Aiym Kaiyrlykyzy1Gauri Bapayeva2Talshyn Ukybassova3Kamila Kenbayeva4Bakytkali Ibrayimov5Alla Lyasova6Giulio Bonaldo7Giovanni Buzzaccarini8Marco Noventa9Antonio Simone Laganà10Milan Terzic11Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 020000 Nur-Sultan, KazakhstanNational Laboratory of Astana, Nazarbayev University, 010000 Nur-Sultan, KazakhstanClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, KazakhstanClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, KazakhstanClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, KazakhstanDepartment of Pathological Anatomy, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, KazakhstanPathology bureau of Nur-Sultan city Administration, 010000 Nur-Sultan, KazakhstanDepartment of Women and Children’s Health, University of Padua, 35122 Padua, ItalyDepartment of Women and Children’s Health, University of Padua, 35122 Padua, ItalyDepartment of Women and Children’s Health, University of Padua, 35122 Padua, ItalyDepartment of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, 21100 Varese, ItalyClinical Academic Department of Women’s Health, National Research Center of Mother and Child Health, University Medical Center, 020000, Nur-Sultan, KazakhstanBackground: Abnormal uterine bleeding is a common sign which cover various conditions e/o pathologies. Different approaches are used to evaluate this condition. The aim of this study was to investigate the validity of Pipelle biopsy for endometrial sampling in Kazakhstani women with abnormal uterine bleeding. For this reason, we carried out a prospective study of 120 patients who underwent endometrial sampling due to abnormal uterine bleeding in a tertiary hospital setting in Kazakhstan. Methods: Statistics included descriptive analysis to evaluate the frequency of various endometrial conditions. The validity of Pipelle biopsy sampling was calculated by estimating sensitivity, specificity, accuracy, and positive and negative predictive values. For the Pipelle sampling validity assessment, we analyzed 120 samples, as 21 patients with insufficient samples were excluded. Results: Overall, concordance in histopathologic results was 92.93%. Pipelle sampling identified two cases of adenocarcinoma in our group. Moreover, endometrial hyperplasia was detected with 71.43% sensitivity, 98.82% specificity, PPV of 90.91% and NPV of 95.45%. However, the Pipelle reliability was low in cases of endometrial polyps. In conclusion, the Pipelle method was found to be valid for the diagnosis of endometrial hyperplasia and adenocarcinoma with high SN, SP, PPV and NPV. Conclusions: The Pipelle technique for evaluation of abnormal uterine bleeding in the Kazakhstani health care setting is a useful method with the highest efficacy in ruling out endometrial hyperplasia and diagnosing adenocarcinoma. If endometrial polyp was suspected under ultrasound scan in patients with abnormal uterine bleeding, physicians should consider other tools for endometrial sampling.https://www.imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.2510pipelledilatation and curettageabnormal uterine bleedingpostmenopausal bleedingendometrial hyperplasia |
| spellingShingle | Gulzhanat Aimagambetova Aiym Kaiyrlykyzy Gauri Bapayeva Talshyn Ukybassova Kamila Kenbayeva Bakytkali Ibrayimov Alla Lyasova Giulio Bonaldo Giovanni Buzzaccarini Marco Noventa Antonio Simone Laganà Milan Terzic Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting Clinical and Experimental Obstetrics & Gynecology pipelle dilatation and curettage abnormal uterine bleeding postmenopausal bleeding endometrial hyperplasia |
| title | Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting |
| title_full | Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting |
| title_fullStr | Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting |
| title_full_unstemmed | Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting |
| title_short | Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting |
| title_sort | validation of pipelle endometrial biopsy in patients with abnormal uterine bleeding in kazakhstani healthcare setting |
| topic | pipelle dilatation and curettage abnormal uterine bleeding postmenopausal bleeding endometrial hyperplasia |
| url | https://www.imrpress.com/journal/CEOG/48/3/10.31083/j.ceog.2021.03.2510 |
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