Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study
ABSTRACT Inhalation of wood smoke (WS) has been associated with increased risk of cardiovascular events, including heart attacks and strokes, both of which are caused in part by the thrombotic occlusion of blood vessels. To characterize the effects of WS on levels of established, circulating prothro...
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| Format: | Article |
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Wiley
2025-07-01
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| Series: | FASEB BioAdvances |
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| Online Access: | https://doi.org/10.1096/fba.2025-00125 |
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| author | Dre' Von A. Dobson Lori A. Holle Kohei Tatsumi Meghan E. Rebuli Nigel Mackman Alisa S. Wolberg Ilona Jaspers |
| author_facet | Dre' Von A. Dobson Lori A. Holle Kohei Tatsumi Meghan E. Rebuli Nigel Mackman Alisa S. Wolberg Ilona Jaspers |
| author_sort | Dre' Von A. Dobson |
| collection | DOAJ |
| description | ABSTRACT Inhalation of wood smoke (WS) has been associated with increased risk of cardiovascular events, including heart attacks and strokes, both of which are caused in part by the thrombotic occlusion of blood vessels. To characterize the effects of WS on levels of established, circulating prothrombotic biomarkers, healthy human subjects at rest were exposed to WS (500 μg/m3) or filtered air for 2 h. Plasma samples were then used to assess markers of endogenous procoagulant activity: cellular activation (tissue factor‐positive extracellular vesicles, TF + EVs), thrombin‐antithrombin complexes (TAT), fibrin formation/breakdown (D‐dimer), and thrombin generation potential. No significant differences in TF + EVs, TATs, D‐dimer, or thrombin generation parameters were detected between WS‐ or filtered air‐exposed individuals. Although females had significantly higher TATs and D‐dimers, and slightly but non‐significantly shorter thrombin generation lag times than males, there were no significant differences between WS‐ or air‐exposed males or females in any measurements. These data suggest that acute WS exposure does not increase prothrombotic biomarkers in plasma. |
| format | Article |
| id | doaj-art-6dfcd97f36014bd891dbe4483f2e5d70 |
| institution | DOAJ |
| issn | 2573-9832 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | FASEB BioAdvances |
| spelling | doaj-art-6dfcd97f36014bd891dbe4483f2e5d702025-08-20T03:14:32ZengWileyFASEB BioAdvances2573-98322025-07-0177n/an/a10.1096/fba.2025-00125Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure StudyDre' Von A. Dobson0Lori A. Holle1Kohei Tatsumi2Meghan E. Rebuli3Nigel Mackman4Alisa S. Wolberg5Ilona Jaspers6Curriculum in Toxicology and Environmental Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USADepartment of Pathology and Laboratory Medicine and UNC Blood Research Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USADepartment of Medicine and UNC Blood Research Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USACurriculum in Toxicology and Environmental Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USADepartment of Medicine and UNC Blood Research Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USADepartment of Pathology and Laboratory Medicine and UNC Blood Research Center The University of North Carolina at Chapel Hill Chapel Hill North Carolina USACurriculum in Toxicology and Environmental Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USAABSTRACT Inhalation of wood smoke (WS) has been associated with increased risk of cardiovascular events, including heart attacks and strokes, both of which are caused in part by the thrombotic occlusion of blood vessels. To characterize the effects of WS on levels of established, circulating prothrombotic biomarkers, healthy human subjects at rest were exposed to WS (500 μg/m3) or filtered air for 2 h. Plasma samples were then used to assess markers of endogenous procoagulant activity: cellular activation (tissue factor‐positive extracellular vesicles, TF + EVs), thrombin‐antithrombin complexes (TAT), fibrin formation/breakdown (D‐dimer), and thrombin generation potential. No significant differences in TF + EVs, TATs, D‐dimer, or thrombin generation parameters were detected between WS‐ or filtered air‐exposed individuals. Although females had significantly higher TATs and D‐dimers, and slightly but non‐significantly shorter thrombin generation lag times than males, there were no significant differences between WS‐ or air‐exposed males or females in any measurements. These data suggest that acute WS exposure does not increase prothrombotic biomarkers in plasma.https://doi.org/10.1096/fba.2025-00125controlled exposurehumansplasmathrombosiswoodsmoke |
| spellingShingle | Dre' Von A. Dobson Lori A. Holle Kohei Tatsumi Meghan E. Rebuli Nigel Mackman Alisa S. Wolberg Ilona Jaspers Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study FASEB BioAdvances controlled exposure humans plasma thrombosis woodsmoke |
| title | Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study |
| title_full | Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study |
| title_fullStr | Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study |
| title_full_unstemmed | Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study |
| title_short | Prothrombotic Biomarkers Are Not Altered by Wood Smoke: A Pilot Controlled Exposure Study |
| title_sort | prothrombotic biomarkers are not altered by wood smoke a pilot controlled exposure study |
| topic | controlled exposure humans plasma thrombosis woodsmoke |
| url | https://doi.org/10.1096/fba.2025-00125 |
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