Cerebral developmental venous anomalies in children with mismatch repair deficiency

Background. Constitutional mismatch repair deficiency (CMMRD) is one of the rare cancer predisposition syndromes. The aim of this study was to evaluate the cerebral developmental venous anomalies in children with central nervous system tumors associated with CMMRD, an area in which there is e...

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Main Authors: Buket Kara, Yahya Paksoy, Ahmet Okay Çağlayan, Nusret Seher, Hilal Akbaş, Yavuz Köksal
Format: Article
Language:English
Published: Hacettepe University Institute of Child Health 2022-12-01
Series:The Turkish Journal of Pediatrics
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Online Access:https://turkjpediatr.org/article/view/248
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author Buket Kara
Yahya Paksoy
Ahmet Okay Çağlayan
Nusret Seher
Hilal Akbaş
Yavuz Köksal
author_facet Buket Kara
Yahya Paksoy
Ahmet Okay Çağlayan
Nusret Seher
Hilal Akbaş
Yavuz Köksal
author_sort Buket Kara
collection DOAJ
description Background. Constitutional mismatch repair deficiency (CMMRD) is one of the rare cancer predisposition syndromes. The aim of this study was to evaluate the cerebral developmental venous anomalies in children with central nervous system tumors associated with CMMRD, an area in which there is extremely little experience. Methods. Data from children diagnosed with medulloblastoma and high grade central nervous sytem tumor were retrospectively collected. According to the European CMMRD criteria, nine patients were diagnosed as CMMRD syndrome and the others consisted of the group without CMMRD. All radiological examinations of these children were retrospectively reviewed. Whole exome sequencing was performed to index cases` germline DNA. Results. Nine children from four families, six females and three males, were studied. The median age at the first tumor diagnosis was 4.5 years (range, 9 months to 14 years). All CMMRD patients had café au lait spots, but none fulfilled the diagnostic criteria for neurofibromatosis. The patients developed high-grade glial tumor (n: 7) and medulloblastoma (n: 2). The affected genes in the three families were MSH6 [c.478C > T (p.Gln160Ter)], MSH6 [c.2871dupC (p.Phe958LeufsTer5)] and MLH1 [c.236G > A(p.Arg79Lys)], respectively. Seven patients had multiple developmental venous anomalies; six patients had leptomeningeal enhancement; and five patients had cavernomas. None of these findings were present in the group without CMMRD. Conclusions. Constitutional mismatch repair deficiency should be considered when multiple developmental venous anomalies, cavernomas, and leptomeningeal enhancement are detected, especially in patients with café au lait spots.
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spelling doaj-art-6df618f08a084a71b746bb021acf79f52025-08-20T02:01:51ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212022-12-0164610.24953/turkjped.2021.3921Cerebral developmental venous anomalies in children with mismatch repair deficiencyBuket Kara0Yahya PaksoyAhmet Okay ÇağlayanNusret Seher1Hilal Akbaş2Yavuz Köksal3Departments of Pediatric Hematology and Oncology, Selcuk University, Faculty of Medicine, Konya, Türkiye.Departments of Radiology, Selcuk University, Faculty of Medicine, Konya, Türkiye.Department of Pediatric Hematology and Oncology, Sağlık Bilimleri University, Hamidiye Faculty of Medicine, Ministry of Health Konya City Hospital, Konya, Türkiye.Departments of Pediatric Hematology and Oncology, Selcuk University, Faculty of Medicine, Konya, Türkiye. Background. Constitutional mismatch repair deficiency (CMMRD) is one of the rare cancer predisposition syndromes. The aim of this study was to evaluate the cerebral developmental venous anomalies in children with central nervous system tumors associated with CMMRD, an area in which there is extremely little experience. Methods. Data from children diagnosed with medulloblastoma and high grade central nervous sytem tumor were retrospectively collected. According to the European CMMRD criteria, nine patients were diagnosed as CMMRD syndrome and the others consisted of the group without CMMRD. All radiological examinations of these children were retrospectively reviewed. Whole exome sequencing was performed to index cases` germline DNA. Results. Nine children from four families, six females and three males, were studied. The median age at the first tumor diagnosis was 4.5 years (range, 9 months to 14 years). All CMMRD patients had café au lait spots, but none fulfilled the diagnostic criteria for neurofibromatosis. The patients developed high-grade glial tumor (n: 7) and medulloblastoma (n: 2). The affected genes in the three families were MSH6 [c.478C > T (p.Gln160Ter)], MSH6 [c.2871dupC (p.Phe958LeufsTer5)] and MLH1 [c.236G > A(p.Arg79Lys)], respectively. Seven patients had multiple developmental venous anomalies; six patients had leptomeningeal enhancement; and five patients had cavernomas. None of these findings were present in the group without CMMRD. Conclusions. Constitutional mismatch repair deficiency should be considered when multiple developmental venous anomalies, cavernomas, and leptomeningeal enhancement are detected, especially in patients with café au lait spots. https://turkjpediatr.org/article/view/248cavernomascentral nervous system tumorconstitutional mismatch repair deficiencydevelopmental venous anomaliesleptomeningeal enhancement
spellingShingle Buket Kara
Yahya Paksoy
Ahmet Okay Çağlayan
Nusret Seher
Hilal Akbaş
Yavuz Köksal
Cerebral developmental venous anomalies in children with mismatch repair deficiency
The Turkish Journal of Pediatrics
cavernomas
central nervous system tumor
constitutional mismatch repair deficiency
developmental venous anomalies
leptomeningeal enhancement
title Cerebral developmental venous anomalies in children with mismatch repair deficiency
title_full Cerebral developmental venous anomalies in children with mismatch repair deficiency
title_fullStr Cerebral developmental venous anomalies in children with mismatch repair deficiency
title_full_unstemmed Cerebral developmental venous anomalies in children with mismatch repair deficiency
title_short Cerebral developmental venous anomalies in children with mismatch repair deficiency
title_sort cerebral developmental venous anomalies in children with mismatch repair deficiency
topic cavernomas
central nervous system tumor
constitutional mismatch repair deficiency
developmental venous anomalies
leptomeningeal enhancement
url https://turkjpediatr.org/article/view/248
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AT ahmetokaycaglayan cerebraldevelopmentalvenousanomaliesinchildrenwithmismatchrepairdeficiency
AT nusretseher cerebraldevelopmentalvenousanomaliesinchildrenwithmismatchrepairdeficiency
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