Fetal Growth Restriction: Mechanisms, Epidemiology, and Management
Abstract. Fetal growth restriction (FGR) is the condition in which a fetus does not reach its intrinsic growth potential and in which the short-term and long-term risks of severe complications are increased. FGR is a frequent complication of pregnancy with a complex etiology and limited management o...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2022-07-01
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| Series: | Maternal-Fetal Medicine |
| Online Access: | http://journals.lww.com/10.1097/FM9.0000000000000161 |
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| author | Hester D. Kamphof Selina Posthuma Sanne J. Gordijn Wessel Ganzevoort Dandan Shi Yiyuan Jiang |
| author_facet | Hester D. Kamphof Selina Posthuma Sanne J. Gordijn Wessel Ganzevoort Dandan Shi Yiyuan Jiang |
| author_sort | Hester D. Kamphof |
| collection | DOAJ |
| description | Abstract. Fetal growth restriction (FGR) is the condition in which a fetus does not reach its intrinsic growth potential and in which the short-term and long-term risks of severe complications are increased. FGR is a frequent complication of pregnancy with a complex etiology and limited management options, other than timely delivery. The most common pathophysiological mechanism is placental insufficiency, due to many underlying causes such as maternal vascular malperfusion, fetal vascular malperfusion and villitis.
Identifying truly growth restricted fetuses remains challenging. To date, FGR is often defined by a cut-off of the estimated fetal weight below a certain percentile on a population-based standard. However, small fetal size as a single marker does not discriminate adequately between fetuses or newborns that are constitutionally small but healthy and fetuses or newborns that are growth restricted and thus at risk for adverse outcomes. In 2016, the consensus definition of FGR was internationally accepted to better pinpoint the FGR population.
In this review we will discuss the contemporary diagnosis and management issues. Different diagnostic markers are considered, like Doppler measurements, estimated fetal growth, interval growth, fetal movements, biomarkers, and placental markers. |
| format | Article |
| id | doaj-art-6df52c80a9bd40dca86978c688fd3ff7 |
| institution | OA Journals |
| issn | 2096-6954 2641-5895 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Maternal-Fetal Medicine |
| spelling | doaj-art-6df52c80a9bd40dca86978c688fd3ff72025-08-20T01:56:56ZengWolters Kluwer HealthMaternal-Fetal Medicine2096-69542641-58952022-07-014318619610.1097/FM9.0000000000000161202207000-00005Fetal Growth Restriction: Mechanisms, Epidemiology, and ManagementHester D. KamphofSelina PosthumaSanne J. GordijnWessel GanzevoortDandan ShiYiyuan JiangAbstract. Fetal growth restriction (FGR) is the condition in which a fetus does not reach its intrinsic growth potential and in which the short-term and long-term risks of severe complications are increased. FGR is a frequent complication of pregnancy with a complex etiology and limited management options, other than timely delivery. The most common pathophysiological mechanism is placental insufficiency, due to many underlying causes such as maternal vascular malperfusion, fetal vascular malperfusion and villitis. Identifying truly growth restricted fetuses remains challenging. To date, FGR is often defined by a cut-off of the estimated fetal weight below a certain percentile on a population-based standard. However, small fetal size as a single marker does not discriminate adequately between fetuses or newborns that are constitutionally small but healthy and fetuses or newborns that are growth restricted and thus at risk for adverse outcomes. In 2016, the consensus definition of FGR was internationally accepted to better pinpoint the FGR population. In this review we will discuss the contemporary diagnosis and management issues. Different diagnostic markers are considered, like Doppler measurements, estimated fetal growth, interval growth, fetal movements, biomarkers, and placental markers.http://journals.lww.com/10.1097/FM9.0000000000000161 |
| spellingShingle | Hester D. Kamphof Selina Posthuma Sanne J. Gordijn Wessel Ganzevoort Dandan Shi Yiyuan Jiang Fetal Growth Restriction: Mechanisms, Epidemiology, and Management Maternal-Fetal Medicine |
| title | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management |
| title_full | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management |
| title_fullStr | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management |
| title_full_unstemmed | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management |
| title_short | Fetal Growth Restriction: Mechanisms, Epidemiology, and Management |
| title_sort | fetal growth restriction mechanisms epidemiology and management |
| url | http://journals.lww.com/10.1097/FM9.0000000000000161 |
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