Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination

Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination

Abstract Progressive neurological decline in multiple sclerosis is associated with axonal loss and synaptic dysfunction in the non-demyelinated normal appearing gray matter (NAGM) and prominently in the cerebellum. In contrast to early disease stages, where synaptic and neuro-axonal pathology correl...

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Main Authors: Melanie Lohrberg, Lena Sünke Mortensen, Carolina Thomas, Franziska Fries, Franziska van der Meer, Alexander Götz, Carolin Landt, Hong Jun Rhee, JeongSeop Rhee, David Gómez-Varela, Manuela Schmidt, Wiebke Möbius, Torben Ruhwedel, Luis A. Pardo, Linus Remling, Nadine Kramann, Claudia Wrzos, Erik Bahn, Christine Stadelmann, Alonso Barrantes-Freer
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-025-03368-9
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