Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis
Abstract Background Changes in gut microbiota metabolism might play an important role in the development of some cancers. However, the causal relationships of gut microbiome-related metabolic pathways in chondrosarcomas and the specific pathways affected remain largely unknown. Methods We used two-s...
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2025-05-01
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| Online Access: | https://doi.org/10.1186/s12885-025-14281-y |
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| author | Xiaoyun Liu Sen Yang Liyun Liu |
| author_facet | Xiaoyun Liu Sen Yang Liyun Liu |
| author_sort | Xiaoyun Liu |
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| description | Abstract Background Changes in gut microbiota metabolism might play an important role in the development of some cancers. However, the causal relationships of gut microbiome-related metabolic pathways in chondrosarcomas and the specific pathways affected remain largely unknown. Methods We used two-sample bidirectional and multivariate Mendelian randomization (MR) to reveal a causal relationship between the gut microbiota metabolic pathway (GMMP) and chondrosarcoma associated gene 1(CSAG1) via the largest available genome-wide association study (GWAS). Results Univariate MR analysis revealed that tetrapyrrole biosynthesis from glutamate, menaquinol 6 biosynthesis, glycogen degradation II, 8-amino-7-oxononanoate biosynthesis, taxadiene biosynthesis, glycolysis and tRNA charging had a significant causal relationship with CSAG1.Multivariate MR analysis suggested that tetrapyrrole biosynthesis, menaquinol 6 biosynthesis, glycogen degradation II, glycolysis and tRNA charging still had a significant causal effect on CSAG1. According to the results of reverse MR analysis, no significant causal effect of CSAG1 on the GMMP was found. Conclusions This study offers further insights into the gut microbiota-mediated mechanism of chondrosarcoma development. |
| format | Article |
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| issn | 1471-2407 |
| language | English |
| publishDate | 2025-05-01 |
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| series | BMC Cancer |
| spelling | doaj-art-6df2c0164c87412da8bc1efc4cba6d5e2025-08-20T02:15:12ZengBMCBMC Cancer1471-24072025-05-0125111210.1186/s12885-025-14281-yCausal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysisXiaoyun Liu0Sen Yang1Liyun Liu2Department of General Medical, The People’s Hospital of Changzhi City, The Third Clinical Hospital of Changzhi Medical UniversityDepartment of Orthopedics, The People’s Hospital of Changzhi City, The Third Clinical Hospital of Changzhi Medical UniversityDepartment of Clinical Medicine, The Peace Hospital of Changzhi City, The First Clinical Hospital of Changzhi Medical UniversityAbstract Background Changes in gut microbiota metabolism might play an important role in the development of some cancers. However, the causal relationships of gut microbiome-related metabolic pathways in chondrosarcomas and the specific pathways affected remain largely unknown. Methods We used two-sample bidirectional and multivariate Mendelian randomization (MR) to reveal a causal relationship between the gut microbiota metabolic pathway (GMMP) and chondrosarcoma associated gene 1(CSAG1) via the largest available genome-wide association study (GWAS). Results Univariate MR analysis revealed that tetrapyrrole biosynthesis from glutamate, menaquinol 6 biosynthesis, glycogen degradation II, 8-amino-7-oxononanoate biosynthesis, taxadiene biosynthesis, glycolysis and tRNA charging had a significant causal relationship with CSAG1.Multivariate MR analysis suggested that tetrapyrrole biosynthesis, menaquinol 6 biosynthesis, glycogen degradation II, glycolysis and tRNA charging still had a significant causal effect on CSAG1. According to the results of reverse MR analysis, no significant causal effect of CSAG1 on the GMMP was found. Conclusions This study offers further insights into the gut microbiota-mediated mechanism of chondrosarcoma development.https://doi.org/10.1186/s12885-025-14281-yMendelian randomizationGut microbiota metabolic pathwayChondrosarcomaChondrosarcoma associated gene 1Causal relationship |
| spellingShingle | Xiaoyun Liu Sen Yang Liyun Liu Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis BMC Cancer Mendelian randomization Gut microbiota metabolic pathway Chondrosarcoma Chondrosarcoma associated gene 1 Causal relationship |
| title | Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis |
| title_full | Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis |
| title_fullStr | Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis |
| title_full_unstemmed | Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis |
| title_short | Causal effect of gut microbiota metabolic pathways on CSAG1 expression in chondrosarcoma: a mendelian randomization analysis |
| title_sort | causal effect of gut microbiota metabolic pathways on csag1 expression in chondrosarcoma a mendelian randomization analysis |
| topic | Mendelian randomization Gut microbiota metabolic pathway Chondrosarcoma Chondrosarcoma associated gene 1 Causal relationship |
| url | https://doi.org/10.1186/s12885-025-14281-y |
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