Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association
Abstract Background Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used worldwide for its cardiometabolic benefits. However, it has recently been associated with nonarteritic anterior ischemic optic neuropathy (NAION). This report presents four clinical cases and explores a...
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BMC
2025-03-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-03958-4 |
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| author | Hamid Ahmadi Steffen Hamann |
| author_facet | Hamid Ahmadi Steffen Hamann |
| author_sort | Hamid Ahmadi |
| collection | DOAJ |
| description | Abstract Background Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used worldwide for its cardiometabolic benefits. However, it has recently been associated with nonarteritic anterior ischemic optic neuropathy (NAION). This report presents four clinical cases and explores a possible association. Case presentation Four male patients were diagnosed with NAION during semaglutide treatment, with treatment durations of less than one year in three cases. All presented with significant optic disc edema and intraretinal fluid on optical coherence tomography, along with crowded optic disc and small Bruch’s membrane opening diameters (< 1.4 mm in three cases). One patient exhibited optic disc drusen. Visual field defects corresponded with ganglion cell layer atrophy on optical coherence tomography. Systemic risk factors varied; two patients had only obesity. Conclusions Our observation suggests that individuals with small Bruch’s membrane opening diameter may be at risk of developing NAION during semaglutide treatment. |
| format | Article |
| id | doaj-art-6df193508a054978b1bfb375852fc04a |
| institution | DOAJ |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-6df193508a054978b1bfb375852fc04a2025-08-20T03:01:41ZengBMCBMC Ophthalmology1471-24152025-03-012511710.1186/s12886-025-03958-4Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible associationHamid Ahmadi0Steffen Hamann1Department of Ophthalmology, Copenhagen University Hospital RigshospitaletDepartment of Ophthalmology, Copenhagen University Hospital RigshospitaletAbstract Background Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used worldwide for its cardiometabolic benefits. However, it has recently been associated with nonarteritic anterior ischemic optic neuropathy (NAION). This report presents four clinical cases and explores a possible association. Case presentation Four male patients were diagnosed with NAION during semaglutide treatment, with treatment durations of less than one year in three cases. All presented with significant optic disc edema and intraretinal fluid on optical coherence tomography, along with crowded optic disc and small Bruch’s membrane opening diameters (< 1.4 mm in three cases). One patient exhibited optic disc drusen. Visual field defects corresponded with ganglion cell layer atrophy on optical coherence tomography. Systemic risk factors varied; two patients had only obesity. Conclusions Our observation suggests that individuals with small Bruch’s membrane opening diameter may be at risk of developing NAION during semaglutide treatment.https://doi.org/10.1186/s12886-025-03958-4Semaglutidenonarteritic anterior ischemic optic neuropathycase-series. |
| spellingShingle | Hamid Ahmadi Steffen Hamann Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association BMC Ophthalmology Semaglutide nonarteritic anterior ischemic optic neuropathy case-series. |
| title | Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association |
| title_full | Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association |
| title_fullStr | Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association |
| title_full_unstemmed | Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association |
| title_short | Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association |
| title_sort | anterior ischemic optic neuropathy in patients treated with semaglutide report of four cases with a possible association |
| topic | Semaglutide nonarteritic anterior ischemic optic neuropathy case-series. |
| url | https://doi.org/10.1186/s12886-025-03958-4 |
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