Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer
BackgroundThis study aimed to screen for risk factors and to assess the predictive value of the monocyte count for the development of moderate-to-severe acute respiratory distress syndrome (ARDS) in patients undergoing one-lung ventilation (OLV) during radical surgery for esophageal cancer.MethodsIn...
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Frontiers Media S.A.
2025-02-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1510788/full |
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| author | Feng Zhang Feng Zhang Shunmei Lu Guilong Wang Hongyang Xu Dongxiao Huang Xiaomin Li |
| author_facet | Feng Zhang Feng Zhang Shunmei Lu Guilong Wang Hongyang Xu Dongxiao Huang Xiaomin Li |
| author_sort | Feng Zhang |
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| description | BackgroundThis study aimed to screen for risk factors and to assess the predictive value of the monocyte count for the development of moderate-to-severe acute respiratory distress syndrome (ARDS) in patients undergoing one-lung ventilation (OLV) during radical surgery for esophageal cancer.MethodsIn this retrospective study, patients with esophageal cancer admitted to the Department of Thoracic Surgery of Wuxi People’s Hospital between January 2017 and January 2021 were selected. Demographic, preoperative, intraoperative, and postoperative (within 2 h) data were collected. Patients were categorized into moderate-to-severe ARDS and non-moderate-to-severe ARDS groups. Multifactorial logistic regression, receiver operating characteristic (ROC), curve-fitting, and Spearman correlation analysis were used to analyze the data.ResultsAfter screening, 255 patients were enrolled, with 18% in moderate-to-severe ARDS group. Regression analysis revealed that postoperative monocyte count was an independent predictor for severe ARDS after surgery (OR = 2.916, 95% CI: 1.082–7.863, p < 0.05). The optimal cut-off value of postoperative monocyte count in predicting moderate-to-severe ARDS was 0.56 × 109/L (AUC = 0.708) with a sensitivity of 67.4% and a specificity of 66.5%. The difference of predictive value between postoperative monocyte count and prediction model (AUC = 0.760) was not statistically significant (p = 0.142). Additionally, a nonlinear connection between postoperative monocyte count and severe ARDS was found using curve fitting.ConclusionThe postoperative monocyte count is an ideal predictor of postoperative moderate-to-severe ARDS in this patient population and can be used for the early diagnosis of patients with severe postoperative ARDS. |
| format | Article |
| id | doaj-art-6df170aedfb049faa606bb9c87b35276 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-6df170aedfb049faa606bb9c87b352762025-02-11T06:59:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15107881510788Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancerFeng Zhang0Feng Zhang1Shunmei Lu2Guilong Wang3Hongyang Xu4Dongxiao Huang5Xiaomin Li6Department of Emergency Medicine, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, ChinaDepartment of Intensive Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, ChinaDepartment of Anesthesiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, ChinaDepartment of Intensive Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, ChinaDepartment of Anesthesiology, Jiangnan University Medical Center, Wuxi, Jiangsu, ChinaDepartment of Emergency Medicine, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, ChinaBackgroundThis study aimed to screen for risk factors and to assess the predictive value of the monocyte count for the development of moderate-to-severe acute respiratory distress syndrome (ARDS) in patients undergoing one-lung ventilation (OLV) during radical surgery for esophageal cancer.MethodsIn this retrospective study, patients with esophageal cancer admitted to the Department of Thoracic Surgery of Wuxi People’s Hospital between January 2017 and January 2021 were selected. Demographic, preoperative, intraoperative, and postoperative (within 2 h) data were collected. Patients were categorized into moderate-to-severe ARDS and non-moderate-to-severe ARDS groups. Multifactorial logistic regression, receiver operating characteristic (ROC), curve-fitting, and Spearman correlation analysis were used to analyze the data.ResultsAfter screening, 255 patients were enrolled, with 18% in moderate-to-severe ARDS group. Regression analysis revealed that postoperative monocyte count was an independent predictor for severe ARDS after surgery (OR = 2.916, 95% CI: 1.082–7.863, p < 0.05). The optimal cut-off value of postoperative monocyte count in predicting moderate-to-severe ARDS was 0.56 × 109/L (AUC = 0.708) with a sensitivity of 67.4% and a specificity of 66.5%. The difference of predictive value between postoperative monocyte count and prediction model (AUC = 0.760) was not statistically significant (p = 0.142). Additionally, a nonlinear connection between postoperative monocyte count and severe ARDS was found using curve fitting.ConclusionThe postoperative monocyte count is an ideal predictor of postoperative moderate-to-severe ARDS in this patient population and can be used for the early diagnosis of patients with severe postoperative ARDS.https://www.frontiersin.org/articles/10.3389/fmed.2025.1510788/fullARDSmonocyteesophageal cancerOLVpredictivepostoperative |
| spellingShingle | Feng Zhang Feng Zhang Shunmei Lu Guilong Wang Hongyang Xu Dongxiao Huang Xiaomin Li Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer Frontiers in Medicine ARDS monocyte esophageal cancer OLV predictive postoperative |
| title | Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer |
| title_full | Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer |
| title_fullStr | Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer |
| title_full_unstemmed | Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer |
| title_short | Predictive value of the monocyte count for determining the risk of postoperative moderate-to-severe ARDS in patients undergoing one-lung ventilation during radical treatment of esophageal cancer |
| title_sort | predictive value of the monocyte count for determining the risk of postoperative moderate to severe ards in patients undergoing one lung ventilation during radical treatment of esophageal cancer |
| topic | ARDS monocyte esophageal cancer OLV predictive postoperative |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1510788/full |
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