Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis.

Inhibition of nitric oxide (NO) signaling may contribute to pathological activation of the vascular endothelium during severe malaria infection. Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an...

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Main Authors: Jessica H Chertow, Matthew S Alkaitis, Glenn Nardone, Allison K Ikeda, Aubrey J Cunnington, Joseph Okebe, Augustine O Ebonyi, Madi Njie, Simon Correa, Shamanthi Jayasooriya, Climent Casals-Pascual, Oliver Billker, David J Conway, Michael Walther, Hans Ackerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005119
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