Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells
One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including,...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317692227 |
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| _version_ | 1849412030520360960 |
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| author | Joachim Bischof Mike-Andrew Westhoff Johanna Elisabeth Wagner Marc-Eric Halatsch Stephanie Trentmann Uwe Knippschild Christian Rainer Wirtz Timo Burster |
| author_facet | Joachim Bischof Mike-Andrew Westhoff Johanna Elisabeth Wagner Marc-Eric Halatsch Stephanie Trentmann Uwe Knippschild Christian Rainer Wirtz Timo Burster |
| author_sort | Joachim Bischof |
| collection | DOAJ |
| description | One major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review. |
| format | Article |
| id | doaj-art-6deb093995b74f7a8eeafdccccc9cd4a |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-6deb093995b74f7a8eeafdccccc9cd4a2025-08-20T03:34:33ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317692227Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cellsJoachim Bischof0Mike-Andrew Westhoff1Johanna Elisabeth Wagner2Marc-Eric Halatsch3Stephanie Trentmann4Uwe Knippschild5Christian Rainer Wirtz6Timo Burster7Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment of Neurosurgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment of Neurosurgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment of Neurosurgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyDepartment of Neurosurgery, Surgery Center, Ulm University Medical Center, Ulm University, Ulm, GermanyOne major obstacle in cancer therapy is chemoresistance leading to tumor recurrence and metastasis. Cancer stem cells, in particular glioblastoma stem cells, are highly resistant to chemotherapy, radiation, and immune recognition. In case of immune recognition, several survival mechanisms including, regulation of autophagy, proteases, and cell surface major histocompatibility complex class I molecules, are found in glioblastoma stem cells. In different pathways, cathepsins play a crucial role in processing functional proteins that are necessary for several processes and proper cell function. Consequently, strategies targeting these pathways in glioblastoma stem cells are promising approaches to interfere with tumor cell survival and will be discussed in this review.https://doi.org/10.1177/1010428317692227 |
| spellingShingle | Joachim Bischof Mike-Andrew Westhoff Johanna Elisabeth Wagner Marc-Eric Halatsch Stephanie Trentmann Uwe Knippschild Christian Rainer Wirtz Timo Burster Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells Tumor Biology |
| title | Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells |
| title_full | Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells |
| title_fullStr | Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells |
| title_full_unstemmed | Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells |
| title_short | Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells |
| title_sort | cancer stem cells the potential role of autophagy proteolysis and cathepsins in glioblastoma stem cells |
| url | https://doi.org/10.1177/1010428317692227 |
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