Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia
Introduction: Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the setting of hypokalemia. A review of the literature...
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SMC MEDIA SRL
2025-02-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5195 |
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| author | Razan Dankar Salim Barakat Elie El-Charabaty Syed Salman Hamid Hashmi Suzanne E. El Sayegh |
| author_facet | Razan Dankar Salim Barakat Elie El-Charabaty Syed Salman Hamid Hashmi Suzanne E. El Sayegh |
| author_sort | Razan Dankar |
| collection | DOAJ |
| description | Introduction: Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the setting of hypokalemia. A review of the literature showed that it is the seventh documented example of BrP induced by hypokalemia alongside HPP.
Case description: A 43-year-old man presented to the emergency department with lower limb weakness. He attributed his symptoms to a substantial meal consumed after breaking his Ramadan fast, recalling a similar episode following heavy meals in the past. The patient was alert and oriented but demonstrated reduced strength in both upper and lower limbs. ECG revealed a Brugada type 1 pattern. Laboratory analysis revealed hypokalemia (2.5 mmol/l), elevated creatine kinase (326 U/l), and normal thyroid function. Following potassium supplementation, his symptoms resolved, and his ECG normalized.
Discussion: HPP occurs in the context of increased carbohydrate intake, potentially leading to rapid insulin release and activation of Na-K ATPase, enhancing cellular potassium absorption and lowering serum potassium levels. Symptoms range from weakness and fatigue to severe neuromuscular weakness and cardiac arrhythmias. Investigating hypokalemia requires excluding hypomagnesemia, thyroid function tests, and metabolic acidosis/alkalosis before considering HPP. Management involves gradual oral potassium repletion to avoid the risk of hyperkalemia associated with intravenous administration.
Conclusion: Clinicians should consider including HPP in differential diagnoses of patients presenting with weakness. In this case, electrophysiological evaluation suggested Brugada pattern induced by hypokalemia, which resolved with potassium supplementation. |
| format | Article |
| id | doaj-art-6dea861eef984b8992bf2f4f678407f8 |
| institution | DOAJ |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-6dea861eef984b8992bf2f4f678407f82025-08-20T03:16:23ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-02-0110.12890/2025_0051954730Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemiaRazan Dankar0Salim Barakat1Elie El-Charabaty2Syed Salman Hamid Hashmi3Suzanne E. El Sayegh4Department of Internal Medicine, Staten Island University Hospital, New York City, USADepartment of Internal Medicine, Staten Island University Hospital, New York City, USADepartment of Internal Medicine, Staten Island University Hospital, New York City, USA; Department of Nephrology, Staten Island University Hospital, New York City, USADepartment of Internal Medicine, Staten Island University Hospital, New York City, USA; Department of Nephrology, Staten Island University Hospital, New York City, USADepartment of Internal Medicine, Staten Island University Hospital, New York City, USA; Department of Nephrology, Staten Island University Hospital, New York City, USAIntroduction: Hypokalemic periodic paralysis (HPP) presents a diagnostic challenge due to the painless muscle weakness it causes. This case discusses a patient with HPP along with electrocardiogram (ECG) findings of Brugada phenocopies (BrP) in the setting of hypokalemia. A review of the literature showed that it is the seventh documented example of BrP induced by hypokalemia alongside HPP. Case description: A 43-year-old man presented to the emergency department with lower limb weakness. He attributed his symptoms to a substantial meal consumed after breaking his Ramadan fast, recalling a similar episode following heavy meals in the past. The patient was alert and oriented but demonstrated reduced strength in both upper and lower limbs. ECG revealed a Brugada type 1 pattern. Laboratory analysis revealed hypokalemia (2.5 mmol/l), elevated creatine kinase (326 U/l), and normal thyroid function. Following potassium supplementation, his symptoms resolved, and his ECG normalized. Discussion: HPP occurs in the context of increased carbohydrate intake, potentially leading to rapid insulin release and activation of Na-K ATPase, enhancing cellular potassium absorption and lowering serum potassium levels. Symptoms range from weakness and fatigue to severe neuromuscular weakness and cardiac arrhythmias. Investigating hypokalemia requires excluding hypomagnesemia, thyroid function tests, and metabolic acidosis/alkalosis before considering HPP. Management involves gradual oral potassium repletion to avoid the risk of hyperkalemia associated with intravenous administration. Conclusion: Clinicians should consider including HPP in differential diagnoses of patients presenting with weakness. In this case, electrophysiological evaluation suggested Brugada pattern induced by hypokalemia, which resolved with potassium supplementation.https://www.ejcrim.com/index.php/EJCRIM/article/view/5195hypokalemiahypokalemic periodic paralysisbrugada phenocopy |
| spellingShingle | Razan Dankar Salim Barakat Elie El-Charabaty Syed Salman Hamid Hashmi Suzanne E. El Sayegh Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia European Journal of Case Reports in Internal Medicine hypokalemia hypokalemic periodic paralysis brugada phenocopy |
| title | Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia |
| title_full | Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia |
| title_fullStr | Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia |
| title_full_unstemmed | Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia |
| title_short | Unraveling an uncommon encounter: hypokalemic periodic paralysis with Brugada phenocopy amidst hypokalemia |
| title_sort | unraveling an uncommon encounter hypokalemic periodic paralysis with brugada phenocopy amidst hypokalemia |
| topic | hypokalemia hypokalemic periodic paralysis brugada phenocopy |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5195 |
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