Use of a Novel Passive E-Nose to Monitor Fermentable Prebiotic Fiber Consumption

Use of a Novel Passive E-Nose to Monitor Fermentable Prebiotic Fiber Consumption

We developed a home-based electronic nose (E-Nose) to passively monitor volatile organic compounds (VOCs) emitted following bowel movements and assessed its validity by correlating the output with prebiotic fiber intake. Healthy, non-overweight participants followed a three-week protocol which inclu...

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Bibliographic Details
Main Authors: Lawrence Kosinski, Phillip A. Engen, Barbara Swanson, Michelle Villanueva, Maliha Shaikh, Stefan J. Green, Ankur Naqib, Bruce Hamaker, Thaisa M. Cantu-Jungles, Ali Keshavarzian
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Sensors
Subjects:
electronic nose
microbiota modulation
prebiotics
volatile organic compounds
Online Access:https://www.mdpi.com/1424-8220/25/3/797
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Summary:We developed a home-based electronic nose (E-Nose) to passively monitor volatile organic compounds (VOCs) emitted following bowel movements and assessed its validity by correlating the output with prebiotic fiber intake. Healthy, non-overweight participants followed a three-week protocol which included the following: (1) installing the E-Nose in their bathroom; (2) activating the device following each bowel movement; (3) recording their dietary intake; (4) consuming a fiber bar (RiteCarbs) containing a blend of 10 g of prebiotic fiber daily during weeks two and three; and (5) submit stool specimens at the beginning and end of the study for 16S rRNA gene sequencing and analysis. Participants’ fecal microbiome displayed significantly increased relative abundance of putative total SCFA-producing genera (<i>p</i> = 0.0323) [total acetate-producing genera (<i>p</i> = 0.0214), total butyrate-producing genera (<i>p</i> = 0.0131)] and decreased Gram-negative proinflammatory genera (<i>p</i> = 0.0468). Prebiotic intervention significantly increased the participants’ fiber intake (<i>p</i> = 0.0152), E-Nose Min/Max (<i>p</i> = 0.0339), and area over the curve in VOC–to–fiber output (<i>p</i> = 0.0044). Increased fiber intake was negatively associated (<i>R</i><sup>2</sup> = 0.53, <i>p</i> = 0.026) with decreased relative abundance of putative Gram-negative proinflammatory genera. This proof-of-concept study demonstrates that a prototype E-Nose can noninvasively detect a direct connection between fiber intake and VOC outputs in a home-based environment.
ISSN:1424-8220

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