Drug Target Identification and Elucidation of Natural Inhibitors for : An Study
Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound...
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| Format: | Article |
| Language: | English |
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BioMed Central
2016-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-14-241.pdf |
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| author | Surya Narayan Rath Manisha Ray Animesh Pattnaik Sukanta Kumar Pradhan |
| author_facet | Surya Narayan Rath Manisha Ray Animesh Pattnaik Sukanta Kumar Pradhan |
| author_sort | Surya Narayan Rath |
| collection | DOAJ |
| description | Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. PRJNA28135) from genome database of National Centre for Biotechnology information. In this regards, the inhibitory effect of nine natural compounds like ajoene (Allium sativum), allicin (A. sativum), cinnamaldehyde (Cinnamomum cassia), curcumin (Curcuma longa), gallotannin (active component of green tea and red wine), isoorientin (Anthopterus wardii), isovitexin (A. wardii), neral (Melissa officinalis), and vitexin (A. wardii) have been acknowledged with anti-bacterial properties and hence tested against identified drug target of B. petrii by implicating computational approach. The in silico studies revealed the hypothesis that lpxD could be a potential drug target and with recommendation of a strong inhibitory effect of selected natural compounds against infection caused due to B. petrii, would be further validated through in vitro experiments. |
| format | Article |
| id | doaj-art-6de0c30977ed49099fa7cab11198f4df |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-6de0c30977ed49099fa7cab11198f4df2025-02-02T04:58:00ZengBioMed CentralGenomics & Informatics1598-866X2234-07422016-12-0114424125410.5808/GI.2016.14.4.241184Drug Target Identification and Elucidation of Natural Inhibitors for : An StudySurya Narayan Rath0Manisha Ray1Animesh Pattnaik2Sukanta Kumar Pradhan3BIF Centre, Department of Bioinformatics, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India.BIF Centre, Department of Bioinformatics, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India.BIF Centre, Department of Bioinformatics, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India.BIF Centre, Department of Bioinformatics, Orissa University of Agriculture and Technology, Bhubaneswar 751003, India.Environmental microbes like Bordetella petrii has been established as a causative agent for various infectious diseases in human. Again, development of drug resistance in B. petrii challenged to combat against the infection. Identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. PRJNA28135) from genome database of National Centre for Biotechnology information. In this regards, the inhibitory effect of nine natural compounds like ajoene (Allium sativum), allicin (A. sativum), cinnamaldehyde (Cinnamomum cassia), curcumin (Curcuma longa), gallotannin (active component of green tea and red wine), isoorientin (Anthopterus wardii), isovitexin (A. wardii), neral (Melissa officinalis), and vitexin (A. wardii) have been acknowledged with anti-bacterial properties and hence tested against identified drug target of B. petrii by implicating computational approach. The in silico studies revealed the hypothesis that lpxD could be a potential drug target and with recommendation of a strong inhibitory effect of selected natural compounds against infection caused due to B. petrii, would be further validated through in vitro experiments.http://genominfo.org/upload/pdf/gni-14-241.pdfcommunicable diseasescomputer simulationdrug delivery systemsinhibitory effect techniquesnatural Compounds |
| spellingShingle | Surya Narayan Rath Manisha Ray Animesh Pattnaik Sukanta Kumar Pradhan Drug Target Identification and Elucidation of Natural Inhibitors for : An Study Genomics & Informatics communicable diseases computer simulation drug delivery systems inhibitory effect techniques natural Compounds |
| title | Drug Target Identification and Elucidation of Natural Inhibitors for : An Study |
| title_full | Drug Target Identification and Elucidation of Natural Inhibitors for : An Study |
| title_fullStr | Drug Target Identification and Elucidation of Natural Inhibitors for : An Study |
| title_full_unstemmed | Drug Target Identification and Elucidation of Natural Inhibitors for : An Study |
| title_short | Drug Target Identification and Elucidation of Natural Inhibitors for : An Study |
| title_sort | drug target identification and elucidation of natural inhibitors for an study |
| topic | communicable diseases computer simulation drug delivery systems inhibitory effect techniques natural Compounds |
| url | http://genominfo.org/upload/pdf/gni-14-241.pdf |
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