Recent Advances on the Regulations of Organic Anion Transporters
The organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes. These anionic molecules include various endogenous and exogenous...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/16/11/1355 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850068243069272064 |
|---|---|
| author | Zhou Yu Guofeng You |
| author_facet | Zhou Yu Guofeng You |
| author_sort | Zhou Yu |
| collection | DOAJ |
| description | The organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes. These anionic molecules include various endogenous and exogenous compounds such as signaling molecules, nutrients, metabolites, toxins, and drugs. Therefore, OATs actively contribute to the systemic homeostasis and efficacy of therapeutics. This article provides a brief overview on recent advances in the understanding of the regulatory mechanisms that control the expression and activity of OATs in both health and diseases. |
| format | Article |
| id | doaj-art-6dc96dcba3764a73a7b4deb8af4a2d8d |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-6dc96dcba3764a73a7b4deb8af4a2d8d2025-08-20T02:48:07ZengMDPI AGPharmaceutics1999-49232024-10-011611135510.3390/pharmaceutics16111355Recent Advances on the Regulations of Organic Anion TransportersZhou Yu0Guofeng You1Department of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USADepartment of Pharmaceutics, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USAThe organic anion transporter (OAT) family of over 10 members within the solute carrier (SLC) superfamily of membrane proteins plays critical roles in facilitating the flux of negatively charged molecules in and out of cell membranes. These anionic molecules include various endogenous and exogenous compounds such as signaling molecules, nutrients, metabolites, toxins, and drugs. Therefore, OATs actively contribute to the systemic homeostasis and efficacy of therapeutics. This article provides a brief overview on recent advances in the understanding of the regulatory mechanisms that control the expression and activity of OATs in both health and diseases.https://www.mdpi.com/1999-4923/16/11/1355drug transporterorganic anion transporterregulationpost-translational modificationdiseasesdrug disposition |
| spellingShingle | Zhou Yu Guofeng You Recent Advances on the Regulations of Organic Anion Transporters Pharmaceutics drug transporter organic anion transporter regulation post-translational modification diseases drug disposition |
| title | Recent Advances on the Regulations of Organic Anion Transporters |
| title_full | Recent Advances on the Regulations of Organic Anion Transporters |
| title_fullStr | Recent Advances on the Regulations of Organic Anion Transporters |
| title_full_unstemmed | Recent Advances on the Regulations of Organic Anion Transporters |
| title_short | Recent Advances on the Regulations of Organic Anion Transporters |
| title_sort | recent advances on the regulations of organic anion transporters |
| topic | drug transporter organic anion transporter regulation post-translational modification diseases drug disposition |
| url | https://www.mdpi.com/1999-4923/16/11/1355 |
| work_keys_str_mv | AT zhouyu recentadvancesontheregulationsoforganicaniontransporters AT guofengyou recentadvancesontheregulationsoforganicaniontransporters |