Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition
The recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical f...
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| Format: | Article |
| Language: | English |
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Radcliffe Medical Media
2020-10-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articles/heart-failure-with-mid-range |
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| author | Davide Margonato Simone Mazzetti Renata De Maria Marco Gorini Massimo Iacoviello Aldo P Maggioni Andrea Mortara |
| author_facet | Davide Margonato Simone Mazzetti Renata De Maria Marco Gorini Massimo Iacoviello Aldo P Maggioni Andrea Mortara |
| author_sort | Davide Margonato |
| collection | DOAJ |
| description | The recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical features with other HF phenotypes, such as a high prevalence of ischaemic aetiology, as in HF with reduced EF (HFrEF), or hypertension and diabetes, as in HF with preserved EF (HFpEF), and benefits from the cornerstone drugs indicated for HFrEF. Among the HF phenotypes, HFmrEF is characterised by the highest rate of transition to either recovery or worsening of the severe systolic dysfunction profile that is the target of disease-modifying therapies, with opposite prognostic implications. This article focuses on the epidemiology, clinical characteristics and therapeutic approaches for HFmrEF, and discusses the major determinants of transition to HFpEF or HFrEF. |
| format | Article |
| id | doaj-art-6dc9153648fd4728bf9feffc607665fb |
| institution | DOAJ |
| issn | 2057-7540 2057-7559 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj-art-6dc9153648fd4728bf9feffc607665fb2025-08-20T02:39:22ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592020-10-01610.15420/cfr.2020.13Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of TransitionDavide Margonato0Simone Mazzetti1Renata De Maria2Marco Gorini3Massimo Iacoviello4Aldo P Maggioni5Andrea Mortara6Department of Clinical Cardiology, Policlinico di Monza, Monza, Italy; Department of Cardiology, University of Pavia, Pavia, ItalyDepartment of Clinical Cardiology, Policlinico di Monza, Monza, ItalyNational Research Council, Institute of Clinical Physiology, ASST Great Metropolitan Hospital Niguarda, Milan, ItalyANMCO Research Center, Florence, ItalyDepartment of Medical and Surgical Sciences, University of Foggia, Foggia, ItalyANMCO Research Center, Florence, ItalyDepartment of Clinical Cardiology, Policlinico di Monza, Monza, ItalyThe recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical features with other HF phenotypes, such as a high prevalence of ischaemic aetiology, as in HF with reduced EF (HFrEF), or hypertension and diabetes, as in HF with preserved EF (HFpEF), and benefits from the cornerstone drugs indicated for HFrEF. Among the HF phenotypes, HFmrEF is characterised by the highest rate of transition to either recovery or worsening of the severe systolic dysfunction profile that is the target of disease-modifying therapies, with opposite prognostic implications. This article focuses on the epidemiology, clinical characteristics and therapeutic approaches for HFmrEF, and discusses the major determinants of transition to HFpEF or HFrEF.https://www.cfrjournal.com/articles/heart-failure-with-mid-range |
| spellingShingle | Davide Margonato Simone Mazzetti Renata De Maria Marco Gorini Massimo Iacoviello Aldo P Maggioni Andrea Mortara Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition Cardiac Failure Review |
| title | Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition |
| title_full | Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition |
| title_fullStr | Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition |
| title_full_unstemmed | Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition |
| title_short | Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition |
| title_sort | heart failure with mid range or recovered ejection fraction differential determinants of transition |
| url | https://www.cfrjournal.com/articles/heart-failure-with-mid-range |
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