Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta
Objective: This study aims to explore the role of hypoxia inducible factor-1α (HIF-1α) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present st...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-08-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5243 |
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| author | J.Y. Yan P.P. Chen L.L. Jiang H.L. Zhang Q. Han R.X. Chen Q.J. Zhang |
| author_facet | J.Y. Yan P.P. Chen L.L. Jiang H.L. Zhang Q. Han R.X. Chen Q.J. Zhang |
| author_sort | J.Y. Yan |
| collection | DOAJ |
| description | Objective: This study aims to explore the role of hypoxia inducible factor-1α (HIF-1α) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of HIF-1α in the placenta. Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the HIF-1α protein levels in the placenta. Results: The mean expression of placental HIF-1α in the placenta increta and placenta previa groups was significantly higher than that in the normal placenta. The level of placental HIF-1α in the placenta increta was significantly higher than that in the placenta previa (p < 0.05). The level of placental HIF-1α had no obvious correlation with the accreta site and umbilical cord insertion. Conclusion: The morbidly of adherent placenta is closely correlated to adverse pregnancy outcomes during the perinatal period. Placental HIF-1α is associated with morbidly adherent placenta. |
| format | Article |
| id | doaj-art-6dbe4d27d774416b9e0af8be5211eb11 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-6dbe4d27d774416b9e0af8be5211eb112025-08-20T02:06:12ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-08-0147456557010.31083/j.ceog.2020.04.52430390-6663-47-4-565Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placentaJ.Y. Yan0P.P. Chen1L.L. Jiang2H.L. Zhang3Q. Han4R.X. Chen5Q.J. Zhang6Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. ChinaSecond affiliated hospital of Fujian medical university, Quanzhou, Fujian, 362001, P.R. ChinaFujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. ChinaFujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. ChinaFujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. ChinaFujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. ChinaFujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350001, P.R. ChinaObjective: This study aims to explore the role of hypoxia inducible factor-1α (HIF-1α) in morbidly adherent placenta (MAP). Materials and Methods: Ten pregnant women with placenta increta, 20 pregnant women with placenta previa, and 30 normal pregnant women as controls participated in the present study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to measure the mRNA expression of HIF-1α in the placenta. Enzyme-linked immunosorbent assay (ELISA) was performed to analyze the HIF-1α protein levels in the placenta. Results: The mean expression of placental HIF-1α in the placenta increta and placenta previa groups was significantly higher than that in the normal placenta. The level of placental HIF-1α in the placenta increta was significantly higher than that in the placenta previa (p < 0.05). The level of placental HIF-1α had no obvious correlation with the accreta site and umbilical cord insertion. Conclusion: The morbidly of adherent placenta is closely correlated to adverse pregnancy outcomes during the perinatal period. Placental HIF-1α is associated with morbidly adherent placenta.https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5243hif-1αplacenta incretaplacenta previapathogenesismorbidly adherent placenta |
| spellingShingle | J.Y. Yan P.P. Chen L.L. Jiang H.L. Zhang Q. Han R.X. Chen Q.J. Zhang Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta Clinical and Experimental Obstetrics & Gynecology hif-1α placenta increta placenta previa pathogenesis morbidly adherent placenta |
| title | Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta |
| title_full | Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta |
| title_fullStr | Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta |
| title_full_unstemmed | Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta |
| title_short | Exploration on the relationship between hypoxia inducible factor-1α and morbidly adherent placenta |
| title_sort | exploration on the relationship between hypoxia inducible factor 1α and morbidly adherent placenta |
| topic | hif-1α placenta increta placenta previa pathogenesis morbidly adherent placenta |
| url | https://www.imrpress.com/journal/CEOG/47/4/10.31083/j.ceog.2020.04.5243 |
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