Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma
Background/Aims: Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histology resembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to early lymph node or liver metastasis, but information...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean College of Helicobacter and Upper Gastrointestinal Research
2017-06-01
|
| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.2.88 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412028550086656 |
|---|---|
| author | Jung Bin Yoon Gwang Ha Kim Do Youn Park Young Geum Kim Sung Ik Pyeon Bong Eun Lee Geun Am Song |
| author_facet | Jung Bin Yoon Gwang Ha Kim Do Youn Park Young Geum Kim Sung Ik Pyeon Bong Eun Lee Geun Am Song |
| author_sort | Jung Bin Yoon |
| collection | DOAJ |
| description | Background/Aims: Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histology resembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to early lymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathological features of GHA. Materials and Methods: We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011 and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed. Results: The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevated in 3 of 4 patients. All the tumors were ＞4 cm (range, 4∼12 cm), and 7 tumors were located at the lower third of the stomach. Five tumors were classified as Borrmann’s type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5 received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliative operation and/or chemotherapy. Their median survival time was 11.8 months (range, 1∼36 months). Two patients with elevated serum CEA levels had poor outcomes. Conclusions: GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer with a purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatment might provide some benefit. |
| format | Article |
| id | doaj-art-6db07e6a20924e05a3ddf20454e248e4 |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-6db07e6a20924e05a3ddf20454e248e42025-08-20T03:34:33ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312017-06-01172889310.7704/kjhugr.2017.17.2.88kjhugr.2017.17.2.88Clinicopathological Characteristics of Gastric Hepatoid AdenocarcinomaJung Bin Yoon0Gwang Ha Kim1Do Youn Park2Young Geum Kim3Sung Ik Pyeon4Bong Eun Lee5Geun Am Song6Department of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Pathology, Pusan National University School of Medicine, Busan, KoreaDepartment of Pathology, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaBackground/Aims: Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histology resembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to early lymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathological features of GHA. Materials and Methods: We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011 and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed. Results: The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevated in 3 of 4 patients. All the tumors were ＞4 cm (range, 4∼12 cm), and 7 tumors were located at the lower third of the stomach. Five tumors were classified as Borrmann’s type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5 received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliative operation and/or chemotherapy. Their median survival time was 11.8 months (range, 1∼36 months). Two patients with elevated serum CEA levels had poor outcomes. Conclusions: GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer with a purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatment might provide some benefit.http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.2.88AdenocarcinomaChemotherapyEndoscopyHepatocelluar carcinomaStomach |
| spellingShingle | Jung Bin Yoon Gwang Ha Kim Do Youn Park Young Geum Kim Sung Ik Pyeon Bong Eun Lee Geun Am Song Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma The Korean Journal of Helicobacter and Upper Gastrointestinal Research Adenocarcinoma Chemotherapy Endoscopy Hepatocelluar carcinoma Stomach |
| title | Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma |
| title_full | Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma |
| title_fullStr | Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma |
| title_full_unstemmed | Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma |
| title_short | Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma |
| title_sort | clinicopathological characteristics of gastric hepatoid adenocarcinoma |
| topic | Adenocarcinoma Chemotherapy Endoscopy Hepatocelluar carcinoma Stomach |
| url | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.2.88 |
| work_keys_str_mv | AT jungbinyoon clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma AT gwanghakim clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma AT doyounpark clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma AT younggeumkim clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma AT sungikpyeon clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma AT bongeunlee clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma AT geunamsong clinicopathologicalcharacteristicsofgastrichepatoidadenocarcinoma |