PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW
Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin's lymphoma of B-cells from the extranodal marginal zone of mucosa-associated lymphoid tissue, with rare manifestation in the oral cavity. A 69-year-old woman with a complaint of a sessile normochromic nodule, non-ulce...
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Elsevier
2024-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S253113792402371X |
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| author | DSFPR Chaves ES Tolentino MCD Santos ARC Moreschi HG Lima FV Miranda ILMD Nascimento PSS Santos CL Cardoso |
| author_facet | DSFPR Chaves ES Tolentino MCD Santos ARC Moreschi HG Lima FV Miranda ILMD Nascimento PSS Santos CL Cardoso |
| author_sort | DSFPR Chaves |
| collection | DOAJ |
| description | Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin's lymphoma of B-cells from the extranodal marginal zone of mucosa-associated lymphoid tissue, with rare manifestation in the oral cavity. A 69-year-old woman with a complaint of a sessile normochromic nodule, non-ulcerated surface with telangiectasias, approximately 2 cm in size, in the lower labial mucosa on the left side, firm and well defined on palpation, painless, with an evolution time of 1 month. The patient did not present with any cutaneous or systemic changes. The diagnostic hypothesis was a reactional lesion or a benign neoplasm, so an excisional biopsy was performed. The histopathologic examination revealed numerous lymphoid follicles of various sizes, with germinal centers and monomorphic proliferation of lymphocytes, suggesting reactive lymphoid hyperplasia or non-Hodgkins lymphoma. Immunohistochemical analysis was positive for CD20, CD 43, Bcl2, Kappa, Lambda, IgM and negative for CK AE1/AE3, CD3, CD5, CD10, CD23, BCL-6, cyclin D1 and CD 138. The positive Ki-67 ratio was about 20%. These findings associated with histopathologic characteristics were consistent with a primary MALT lymphoma. The patient was referred to an oncohematology physician. Biopsy analysis confirmed the neoplastic diagnosis with negative margins, ruling out surgical intervention and treatments with chemotherapy or radiation therapy. Primary presentation of MALT lymphoma in the oral cavity is very rare, data are scarce, and the characteristics and clinical outcome of the disease remain controversial. A review of the literature was conducted and 31 manuscripts were identified between 2004 and 2024. Only case reports and case series that included primary oral MALT lymphoma were used in this comparative analysis, with a total of 78 lesions. This case report and brief review demonstrate how rare the primary occurrence of MALT lymphoma in the oral cavity is and emphasize the importance of performing biopsies and anatomopathologic studies of oral lesions. |
| format | Article |
| id | doaj-art-6db0797697da47f6938103be66dd02a6 |
| institution | OA Journals |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-6db0797697da47f6938103be66dd02a62025-08-20T02:17:45ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-10-0146S116410.1016/j.htct.2024.09.2036PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEWDSFPR Chaves0ES Tolentino1MCD Santos2ARC Moreschi3HG Lima4FV Miranda5ILMD Nascimento6PSS Santos7CL Cardoso8Universidade do Distrito Federal (UDF), Brasília, DF, BrazilUniversidade Estadual de Maringá (UEM), Maringá, PR, BrazilUniversidade Estadual de Maringá (UEM), Maringá, PR, BrazilUniversidade Cesumar (UniCesumar), Maringá, PR, BrazilUniversidade Federal do Paraná (UFPR), Curitiba, PR, BrazilUniversidade Cesumar (UniCesumar), Maringá, PR, BrazilFaculdade de Odontologia de Bauru (FOB), Universidade de São Paulo, Bauru, SP, BrazilFaculdade de Odontologia de Bauru (FOB), Universidade de São Paulo, Bauru, SP, BrazilFaculdade de Odontologia de Bauru (FOB), Universidade de São Paulo, Bauru, SP, BrazilMucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin's lymphoma of B-cells from the extranodal marginal zone of mucosa-associated lymphoid tissue, with rare manifestation in the oral cavity. A 69-year-old woman with a complaint of a sessile normochromic nodule, non-ulcerated surface with telangiectasias, approximately 2 cm in size, in the lower labial mucosa on the left side, firm and well defined on palpation, painless, with an evolution time of 1 month. The patient did not present with any cutaneous or systemic changes. The diagnostic hypothesis was a reactional lesion or a benign neoplasm, so an excisional biopsy was performed. The histopathologic examination revealed numerous lymphoid follicles of various sizes, with germinal centers and monomorphic proliferation of lymphocytes, suggesting reactive lymphoid hyperplasia or non-Hodgkins lymphoma. Immunohistochemical analysis was positive for CD20, CD 43, Bcl2, Kappa, Lambda, IgM and negative for CK AE1/AE3, CD3, CD5, CD10, CD23, BCL-6, cyclin D1 and CD 138. The positive Ki-67 ratio was about 20%. These findings associated with histopathologic characteristics were consistent with a primary MALT lymphoma. The patient was referred to an oncohematology physician. Biopsy analysis confirmed the neoplastic diagnosis with negative margins, ruling out surgical intervention and treatments with chemotherapy or radiation therapy. Primary presentation of MALT lymphoma in the oral cavity is very rare, data are scarce, and the characteristics and clinical outcome of the disease remain controversial. A review of the literature was conducted and 31 manuscripts were identified between 2004 and 2024. Only case reports and case series that included primary oral MALT lymphoma were used in this comparative analysis, with a total of 78 lesions. This case report and brief review demonstrate how rare the primary occurrence of MALT lymphoma in the oral cavity is and emphasize the importance of performing biopsies and anatomopathologic studies of oral lesions.http://www.sciencedirect.com/science/article/pii/S253113792402371X |
| spellingShingle | DSFPR Chaves ES Tolentino MCD Santos ARC Moreschi HG Lima FV Miranda ILMD Nascimento PSS Santos CL Cardoso PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW Hematology, Transfusion and Cell Therapy |
| title | PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW |
| title_full | PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW |
| title_fullStr | PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW |
| title_full_unstemmed | PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW |
| title_short | PRIMARY MALT LYMPHOMA IN ORAL CAVITY: CASE REPORT AND REVIEW |
| title_sort | primary malt lymphoma in oral cavity case report and review |
| url | http://www.sciencedirect.com/science/article/pii/S253113792402371X |
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