TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy
We assess the level of tumour necrosis factor alpha (TNF-alpha) in tear fluids and other serum parameters associated with diabetes in different degrees of diabetic retinopathy. We have performed a prospective, nonrandomized, observational study. Study populatio...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/629529 |
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| author | C. Costagliola V. Romano M. De Tollis F. Aceto R. dell’Omo M. R. Romano C. Pedicino F. Semeraro |
| author_facet | C. Costagliola V. Romano M. De Tollis F. Aceto R. dell’Omo M. R. Romano C. Pedicino F. Semeraro |
| author_sort | C. Costagliola |
| collection | DOAJ |
| description | We assess the level of tumour necrosis factor alpha (TNF-alpha) in tear fluids and other serum
parameters associated with diabetes in different degrees of diabetic retinopathy. We have performed a prospective,
nonrandomized, observational study. Study population consisted of 16 healthy subjects (controls) and 32 type 2
diabetic patients: 16 affected by proliferative diabetic retinopathy (PDR) and 16 with nonproliferative retinopathy
(NDPR, background/preproliferative). Body mass index, urinary albumin, blood glucose, HbA1c, and tear levels
of TNF-alpha were measured in all subjects. The value of glycaemia, microalbuminurea, and Body mass index
in diabetic retinopathy groups were higher than those in control group ().
Glycemia in NPDR: 6.6 mmol/L (range: 5.8–6.3); in PDR: 6.7 mmol/L
(range: 6.1–7.2); in control: 5.7 mmol/L (range: 4.9–6.1); microalbuminurea in
NPDR: 10.6 mg/L (range: 5.6–20); in PDR: 25.2 mg/L
(range: 17–40); in control: 5.3 mg/L (range: 2.6–10); Body mass index in
NPDR: 26 Kg/m2 (range: 20.3–40);
in PDR: 28 Kg/m2 (range 20.3–52);
in control: 21 Kg/m2 (range 19–26).
The TNF-alpha concentrations in tears increase with the severity of pathology
and were lower in control group than in diabetic subjects. In the end, the level of TNF-alpha
is highly correlated with severity of diabetic retinopathy and with nephropathy.
Tear fluid collection may be a useful noninvasive method for the detection of proliferative diabetic retinopathy. |
| format | Article |
| id | doaj-art-6db071aaf3134670b3126a0dfd843504 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6db071aaf3134670b3126a0dfd8435042025-08-20T02:06:27ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/629529629529TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic RetinopathyC. Costagliola0V. Romano1M. De Tollis2F. Aceto3R. dell’Omo4M. R. Romano5C. Pedicino6F. Semeraro7Department of Medicine and Health Sciences, University of Molise, Campobasso, ItalySecond University of Naples, Via Pansini 5, 80100 Naples, Italy“Casa di Cura Villa Maria”, Campobasso, ItalyDepartment of Medicine and Health Sciences, University of Molise, Campobasso, ItalyDepartment of Medicine and Health Sciences, University of Molise, Campobasso, ItalyDepartment of Medicine and Health Sciences, University of Molise, Campobasso, Italy“Casa di Cura Villa Maria”, Campobasso, ItalyDepartment of Medical and Surgical Specialities, Radiological Specialities and Public Health, Eye Clinic, University of Brescia, Brescia, ItalyWe assess the level of tumour necrosis factor alpha (TNF-alpha) in tear fluids and other serum parameters associated with diabetes in different degrees of diabetic retinopathy. We have performed a prospective, nonrandomized, observational study. Study population consisted of 16 healthy subjects (controls) and 32 type 2 diabetic patients: 16 affected by proliferative diabetic retinopathy (PDR) and 16 with nonproliferative retinopathy (NDPR, background/preproliferative). Body mass index, urinary albumin, blood glucose, HbA1c, and tear levels of TNF-alpha were measured in all subjects. The value of glycaemia, microalbuminurea, and Body mass index in diabetic retinopathy groups were higher than those in control group (). Glycemia in NPDR: 6.6 mmol/L (range: 5.8–6.3); in PDR: 6.7 mmol/L (range: 6.1–7.2); in control: 5.7 mmol/L (range: 4.9–6.1); microalbuminurea in NPDR: 10.6 mg/L (range: 5.6–20); in PDR: 25.2 mg/L (range: 17–40); in control: 5.3 mg/L (range: 2.6–10); Body mass index in NPDR: 26 Kg/m2 (range: 20.3–40); in PDR: 28 Kg/m2 (range 20.3–52); in control: 21 Kg/m2 (range 19–26). The TNF-alpha concentrations in tears increase with the severity of pathology and were lower in control group than in diabetic subjects. In the end, the level of TNF-alpha is highly correlated with severity of diabetic retinopathy and with nephropathy. Tear fluid collection may be a useful noninvasive method for the detection of proliferative diabetic retinopathy.http://dx.doi.org/10.1155/2013/629529 |
| spellingShingle | C. Costagliola V. Romano M. De Tollis F. Aceto R. dell’Omo M. R. Romano C. Pedicino F. Semeraro TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy Mediators of Inflammation |
| title | TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy |
| title_full | TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy |
| title_fullStr | TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy |
| title_full_unstemmed | TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy |
| title_short | TNF-Alpha Levels in Tears: A Novel Biomarker to Assess the Degree of Diabetic Retinopathy |
| title_sort | tnf alpha levels in tears a novel biomarker to assess the degree of diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2013/629529 |
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