Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects
Introduction. glioblastomas multiforme (grade Iv gliomas) are common and the most aggressive primary tumors of the brain with very unfavorable prognosis. In all previously published papers on epileptiform activity in glioblastomas, not enough information on encephalogram results is presented.Aim. To...
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ABV-press
2022-12-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/819 |
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| author | E. E. Tyagunova A. S. Zakharov A. I. Glukhov V. Z. Dobrokhotova T. I. Shlapakov V. V. Kozlov N. V. Korotkova T. E. Tyagunova |
| author_facet | E. E. Tyagunova A. S. Zakharov A. I. Glukhov V. Z. Dobrokhotova T. I. Shlapakov V. V. Kozlov N. V. Korotkova T. E. Tyagunova |
| author_sort | E. E. Tyagunova |
| collection | DOAJ |
| description | Introduction. glioblastomas multiforme (grade Iv gliomas) are common and the most aggressive primary tumors of the brain with very unfavorable prognosis. In all previously published papers on epileptiform activity in glioblastomas, not enough information on encephalogram results is presented.Aim. To study the features of epileptiform activity in patients with glioblastomas and development of a plan for further study of these patients.Materials and methods. An analysis of articles from Elsevier, Embase, Scopus, The Cochrane Library, global Health, Russian Science Citation Index (RSCI) databases, Scholar, google, web of Science, pubmed search engines and scientific electronic library CyberLeninka was performed. materials were selected considering journal indexing system and citations, scientific novelty of the studies, statistical significance of the results. publications repeating data from previous articles or describing animal experiments were excluded from analysis.Results. During the study, data on mechanisms of epileptiform activity pathogenesis, predisposing factors (tumor location in the temporal, frontal or parietal lobes, IDH-1 and / or IDH-2 gene mutations), treatment options in patients with glioblastomas were systemized. Additionally, and original plan of data accumulation for clinical studied taking into account limitations of the previous studies was developed to increase quality of results interpretation.Conclusion. Epileptiform symptoms in glioblastomas negatively affect patients’ quality of life and lifespan. Currently, researchers actively search for an effective method of treatment of epileptic seizures in patients with glioblastomas. The most effective is combination of temozolomide with valproate and levetiracetam due to good control of seizure frequency, low toxicity, and pharmacological synergy between the drugs. |
| format | Article |
| id | doaj-art-6daa4d7938e54476bdb2080299c8ba73 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-6daa4d7938e54476bdb2080299c8ba732025-08-20T04:00:07ZrusABV-pressОпухоли головы и шеи2222-14682411-46342022-12-0112310211310.17650/2222-1468-2022-12-3-102-113513Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspectsE. E. Tyagunova0A. S. Zakharov1A. I. Glukhov2V. Z. Dobrokhotova3T. I. Shlapakov4V. V. Kozlov5N. V. Korotkova6T. E. Tyagunova7I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaPavlov Ryazan State Medical University, Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; M.V. Lomonosov Moscow State UniversityI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia; N. N. Blokhin National Research Institute of Oncology, Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaPavlov Ryazan State Medical University, Ministry of Health of RussiaLLC “Klassny Doctor”Introduction. glioblastomas multiforme (grade Iv gliomas) are common and the most aggressive primary tumors of the brain with very unfavorable prognosis. In all previously published papers on epileptiform activity in glioblastomas, not enough information on encephalogram results is presented.Aim. To study the features of epileptiform activity in patients with glioblastomas and development of a plan for further study of these patients.Materials and methods. An analysis of articles from Elsevier, Embase, Scopus, The Cochrane Library, global Health, Russian Science Citation Index (RSCI) databases, Scholar, google, web of Science, pubmed search engines and scientific electronic library CyberLeninka was performed. materials were selected considering journal indexing system and citations, scientific novelty of the studies, statistical significance of the results. publications repeating data from previous articles or describing animal experiments were excluded from analysis.Results. During the study, data on mechanisms of epileptiform activity pathogenesis, predisposing factors (tumor location in the temporal, frontal or parietal lobes, IDH-1 and / or IDH-2 gene mutations), treatment options in patients with glioblastomas were systemized. Additionally, and original plan of data accumulation for clinical studied taking into account limitations of the previous studies was developed to increase quality of results interpretation.Conclusion. Epileptiform symptoms in glioblastomas negatively affect patients’ quality of life and lifespan. Currently, researchers actively search for an effective method of treatment of epileptic seizures in patients with glioblastomas. The most effective is combination of temozolomide with valproate and levetiracetam due to good control of seizure frequency, low toxicity, and pharmacological synergy between the drugs.https://ogsh.abvpress.ru/jour/article/view/819glioblastomaepilepsyreactive astrocytesisocitrate dehydrogenaseidh-1idh-2questionnaire |
| spellingShingle | E. E. Tyagunova A. S. Zakharov A. I. Glukhov V. Z. Dobrokhotova T. I. Shlapakov V. V. Kozlov N. V. Korotkova T. E. Tyagunova Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects Опухоли головы и шеи glioblastoma epilepsy reactive astrocytes isocitrate dehydrogenase idh-1 idh-2 questionnaire |
| title | Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects |
| title_full | Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects |
| title_fullStr | Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects |
| title_full_unstemmed | Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects |
| title_short | Features of epileptiform activity in patients with diagnosed glioblastoma: from genetic and biochemical mechanisms to clinical aspects |
| title_sort | features of epileptiform activity in patients with diagnosed glioblastoma from genetic and biochemical mechanisms to clinical aspects |
| topic | glioblastoma epilepsy reactive astrocytes isocitrate dehydrogenase idh-1 idh-2 questionnaire |
| url | https://ogsh.abvpress.ru/jour/article/view/819 |
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