Profiling MHC II immunopeptidome of blood‐stage malaria reveals that cDC1 control the functionality of parasite‐specific CD4 T cells

Profiling MHC II immunopeptidome of blood‐stage malaria reveals that cDC1 control the functionality of parasite‐specific CD4 T cells

Abstract In malaria, CD4 Th1 and T follicular helper (TFH) cells are important for controlling parasite growth, but Th1 cells also contribute to immunopathology. Moreover, various regulatory CD4 T‐cell subsets are critical to hamper pathology. Yet the antigen‐presenting cells controlling Th function...

Full description

Saved in:
Bibliographic Details
Main Authors: Marion Draheim, Myriam F Wlodarczyk, Karine Crozat, Jean‐Michel Saliou, Tchilabalo Dilezitoko Alayi, Stanislas Tomavo, Ali Hassan, Anna Salvioni, Claudia Demarta‐Gatsi, John Sidney, Alessandro Sette, Marc Dalod, Antoine Berry, Olivier Silvie, Nicolas Blanchard
Format: Article
Language:English
Published: Springer Nature 2017-09-01
Series:EMBO Molecular Medicine
Subjects:
CD4 T cell
dendritic cell
malaria
MHC II presentation
Plasmodium berghei
Online Access:https://doi.org/10.15252/emmm.201708123
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items