The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling

The umbilical cord blood exosome MFG-E8 alleviates hypoxic-ischemic encephalopathy brain injury in neonatal rats by restoring autophagy flux and inhibiting ferroptosis through GSK3β/β-catenin signaling

Background: Recent studies have revealed importance of human umbilical cord blood (HUCB)-derived exosomes (HUCB-Exo) in central nervous system diseases, but the role of HUCB-Exo in hypoxic-ischemic encephalopathy (HIE) remains unclear. This study aims to explore the mechanisms of HUCB-Exo in HIE. Me...

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Bibliographic Details
Main Authors: Menghua Zhao, Yizhong Wu, Li Huang, Juanmei Wang, Aimin Zhang
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Regenerative Therapy
Subjects:
Hypoxic-ischemic encephalopathy
HUCB-Exo
MFG-E8
GSK3β/β-catenin pathway
Autophagy
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S235232042500149X
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