Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

Summary: Dendritic cells (DCs) are responsible for maintaining tolerance to harmless antigens in the gut; however, the mechanism by which bacterial metabolites induce DC tolerance remains to be studied. Here, we observed that gut commensal bacterium-derived L-lysine stimulated the serine, glycine, o...

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Bibliographic Details
Main Authors: Qiang Tang, Guangyue Fan, Xianping Peng, Xinyu Sun, Xueting Kong, Lisong Zhang, Chunze Zhang, Yandi Liu, Jianming Yang, Kaiyuan Yu, Chunhui Miao, Zhi Yao, Long Li, Zhi-Song Zhang, Quan Wang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014761
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