Mathematical modeling of food intake and insulin infusion in a patient with type 1 Ddabetes in closed loop
Diabetes mellitus type 1 is a condition in which the pancreas loses its ability to produce enough insulin, increasing the levels of blood glucose. This work presents the design of a mathematical model of the glucose - insulin dynamics of a type 1 diabetes patient, contemplating the contribution to t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Spanish |
| Published: |
Universitat Politècnica de València
2020-04-01
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| Series: | Revista Iberoamericana de Automática e Informática Industrial RIAI |
| Subjects: | |
| Online Access: | https://polipapers.upv.es/index.php/RIAI/article/view/11161 |
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| Summary: | Diabetes mellitus type 1 is a condition in which the pancreas loses its ability to produce enough insulin, increasing the levels of blood glucose. This work presents the design of a mathematical model of the glucose - insulin dynamics of a type 1 diabetes patient, contemplating the contribution to the concentration of blood glucose by the intake of carbohydrates, fats and proteins. The model also includes the absorption dynamics of 5 insulin types, different administration methods of exogenous insulin, and the variation of insulin sensitivity during the day. The model was integrated into a closed-loop insulin regulation algorithm, in order to evaluate the performance of the model and the eficiency of closed-loop treatments, compared to open-loop therapies. The results show the response of the model to different situations of a real patient, and tests of the controller’s performance |
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| ISSN: | 1697-7912 1697-7920 |