The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review
Inner ear disorders, including sensorineural hearing loss, Meniere’s disease, and vestibular neuritis, are prevalent conditions that significantly impact the quality of life. Despite their high incidence, the underlying pathophysiology of these disorders remains elusive, and current treatment option...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/13/10/802 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850205942805692416 |
|---|---|
| author | Antonino Maniaci Marilena Briglia Fabio Allia Giuseppe Montalbano Giovanni Luca Romano Mohamed Amine Zaouali Dorra H’mida Caterina Gagliano Roberta Malaguarnera Mario Lentini Adriana Carol Eleonora Graziano Giovanni Giurdanella |
| author_facet | Antonino Maniaci Marilena Briglia Fabio Allia Giuseppe Montalbano Giovanni Luca Romano Mohamed Amine Zaouali Dorra H’mida Caterina Gagliano Roberta Malaguarnera Mario Lentini Adriana Carol Eleonora Graziano Giovanni Giurdanella |
| author_sort | Antonino Maniaci |
| collection | DOAJ |
| description | Inner ear disorders, including sensorineural hearing loss, Meniere’s disease, and vestibular neuritis, are prevalent conditions that significantly impact the quality of life. Despite their high incidence, the underlying pathophysiology of these disorders remains elusive, and current treatment options are often inadequate. Emerging evidence suggests that pericytes, a type of vascular mural cell specialized to maintain the integrity and function of the microvasculature, may play a crucial role in the development and progression of inner ear disorders. The pericytes are present in the microvasculature of both the cochlea and the vestibular system, where they regulate blood flow, maintain the blood–labyrinth barrier, facilitate angiogenesis, and provide trophic support to neurons. Understanding their role in inner ear disorders may provide valuable insights into the pathophysiology of these conditions and lead to the development of novel diagnostic and therapeutic strategies, improving the standard of living. This comprehensive review aims to provide a detailed overview of the role of pericytes in inner ear disorders, highlighting the anatomy and physiology in the microvasculature, and analyzing the mechanisms that contribute to the development of the disorders. Furthermore, we explore the potential pericyte-targeted therapies, including antioxidant, anti-inflammatory, and angiogenic approaches, as well as gene therapy strategies. |
| format | Article |
| id | doaj-art-6d923ac3f7b64dab945bc0ffbd8066c3 |
| institution | OA Journals |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-6d923ac3f7b64dab945bc0ffbd8066c32025-08-20T02:10:57ZengMDPI AGBiology2079-77372024-10-01131080210.3390/biology13100802The Role of Pericytes in Inner Ear Disorders: A Comprehensive ReviewAntonino Maniaci0Marilena Briglia1Fabio Allia2Giuseppe Montalbano3Giovanni Luca Romano4Mohamed Amine Zaouali5Dorra H’mida6Caterina Gagliano7Roberta Malaguarnera8Mario Lentini9Adriana Carol Eleonora Graziano10Giovanni Giurdanella11Department of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyZebrafish Neuromorphology Laboratory, Department of Veterinary Sciences, University of Messina, 98168 Messina, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyLaboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy, University of Monastir, Avicenne Street, 5019 Monastir, TunisiaDepartment of Cytogenetics and Reproductive Biology, Farhat Hached Hospital, 4021 Sousse, TunisiaDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyInner ear disorders, including sensorineural hearing loss, Meniere’s disease, and vestibular neuritis, are prevalent conditions that significantly impact the quality of life. Despite their high incidence, the underlying pathophysiology of these disorders remains elusive, and current treatment options are often inadequate. Emerging evidence suggests that pericytes, a type of vascular mural cell specialized to maintain the integrity and function of the microvasculature, may play a crucial role in the development and progression of inner ear disorders. The pericytes are present in the microvasculature of both the cochlea and the vestibular system, where they regulate blood flow, maintain the blood–labyrinth barrier, facilitate angiogenesis, and provide trophic support to neurons. Understanding their role in inner ear disorders may provide valuable insights into the pathophysiology of these conditions and lead to the development of novel diagnostic and therapeutic strategies, improving the standard of living. This comprehensive review aims to provide a detailed overview of the role of pericytes in inner ear disorders, highlighting the anatomy and physiology in the microvasculature, and analyzing the mechanisms that contribute to the development of the disorders. Furthermore, we explore the potential pericyte-targeted therapies, including antioxidant, anti-inflammatory, and angiogenic approaches, as well as gene therapy strategies.https://www.mdpi.com/2079-7737/13/10/802inner earpericytessensorineural hearing losspathophysiologypericyte-target therapy |
| spellingShingle | Antonino Maniaci Marilena Briglia Fabio Allia Giuseppe Montalbano Giovanni Luca Romano Mohamed Amine Zaouali Dorra H’mida Caterina Gagliano Roberta Malaguarnera Mario Lentini Adriana Carol Eleonora Graziano Giovanni Giurdanella The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review Biology inner ear pericytes sensorineural hearing loss pathophysiology pericyte-target therapy |
| title | The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review |
| title_full | The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review |
| title_fullStr | The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review |
| title_full_unstemmed | The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review |
| title_short | The Role of Pericytes in Inner Ear Disorders: A Comprehensive Review |
| title_sort | role of pericytes in inner ear disorders a comprehensive review |
| topic | inner ear pericytes sensorineural hearing loss pathophysiology pericyte-target therapy |
| url | https://www.mdpi.com/2079-7737/13/10/802 |
| work_keys_str_mv | AT antoninomaniaci theroleofpericytesininnereardisordersacomprehensivereview AT marilenabriglia theroleofpericytesininnereardisordersacomprehensivereview AT fabioallia theroleofpericytesininnereardisordersacomprehensivereview AT giuseppemontalbano theroleofpericytesininnereardisordersacomprehensivereview AT giovannilucaromano theroleofpericytesininnereardisordersacomprehensivereview AT mohamedaminezaouali theroleofpericytesininnereardisordersacomprehensivereview AT dorrahmida theroleofpericytesininnereardisordersacomprehensivereview AT caterinagagliano theroleofpericytesininnereardisordersacomprehensivereview AT robertamalaguarnera theroleofpericytesininnereardisordersacomprehensivereview AT mariolentini theroleofpericytesininnereardisordersacomprehensivereview AT adrianacaroleleonoragraziano theroleofpericytesininnereardisordersacomprehensivereview AT giovannigiurdanella theroleofpericytesininnereardisordersacomprehensivereview AT antoninomaniaci roleofpericytesininnereardisordersacomprehensivereview AT marilenabriglia roleofpericytesininnereardisordersacomprehensivereview AT fabioallia roleofpericytesininnereardisordersacomprehensivereview AT giuseppemontalbano roleofpericytesininnereardisordersacomprehensivereview AT giovannilucaromano roleofpericytesininnereardisordersacomprehensivereview AT mohamedaminezaouali roleofpericytesininnereardisordersacomprehensivereview AT dorrahmida roleofpericytesininnereardisordersacomprehensivereview AT caterinagagliano roleofpericytesininnereardisordersacomprehensivereview AT robertamalaguarnera roleofpericytesininnereardisordersacomprehensivereview AT mariolentini roleofpericytesininnereardisordersacomprehensivereview AT adrianacaroleleonoragraziano roleofpericytesininnereardisordersacomprehensivereview AT giovannigiurdanella roleofpericytesininnereardisordersacomprehensivereview |