Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results
The generalized assessment of cycloferon immunologic modulator efficacy was carried out to estimate its' therapeutic potency as an adjuvant as a part of basic therapy of pulmonary tuberculosis. Heterogeneity of comparison groups and variability of therapeutic response indicators was taken into...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/125 |
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| author | N. K. Mazina P. V. Mazin R. KH. Khafizyanova |
| author_facet | N. K. Mazina P. V. Mazin R. KH. Khafizyanova |
| author_sort | N. K. Mazina |
| collection | DOAJ |
| description | The generalized assessment of cycloferon immunologic modulator efficacy was carried out to estimate its' therapeutic potency as an adjuvant as a part of basic therapy of pulmonary tuberculosis. Heterogeneity of comparison groups and variability of therapeutic response indicators was taken into account. Nine publications formed the basis of the systematic overview and meta-analysis after being extracted from an array of scientific literary data (531 scientific publications on clinical performance of cycloferon drug). The values of the formalized indicators of cycloferon clinical efficacy (increase in absolute and relative benefits, odds ratio, NNT, etc.) were calculated. Efficacy parameters varied in different randomized clinical trials, but this variability was leveled by uniform design and symmetry of the comparison groups to allow the results interpretation as a reflection of real clinical practice. It is shown that the use of cycloferon to enhance immunogenesis in pharmacotherapy of tuberculosis increases rapid recovery rate by more than 2.7 times and decreases the likelihood of adverse effects. |
| format | Article |
| id | doaj-art-6d91189a760a48e5a5f4da67d03f77f1 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-6d91189a760a48e5a5f4da67d03f77f12025-08-20T03:57:47ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01643-4152410.24411/0235-2990-2019-100013124Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis ResultsN. K. Mazina0P. V. Mazin1R. KH. Khafizyanova2Kirov State Medical UniversityKirov State Medical UniversityKazan State Medical UniversityThe generalized assessment of cycloferon immunologic modulator efficacy was carried out to estimate its' therapeutic potency as an adjuvant as a part of basic therapy of pulmonary tuberculosis. Heterogeneity of comparison groups and variability of therapeutic response indicators was taken into account. Nine publications formed the basis of the systematic overview and meta-analysis after being extracted from an array of scientific literary data (531 scientific publications on clinical performance of cycloferon drug). The values of the formalized indicators of cycloferon clinical efficacy (increase in absolute and relative benefits, odds ratio, NNT, etc.) were calculated. Efficacy parameters varied in different randomized clinical trials, but this variability was leveled by uniform design and symmetry of the comparison groups to allow the results interpretation as a reflection of real clinical practice. It is shown that the use of cycloferon to enhance immunogenesis in pharmacotherapy of tuberculosis increases rapid recovery rate by more than 2.7 times and decreases the likelihood of adverse effects.https://www.antibiotics-chemotherapy.ru/jour/article/view/125tuberculosis (pulmonary form)meta-analysisodds ratiounified indicators of clinical efficacyoutcomes frequencymodels of fixed and random effectsheterogeneity and sensitivity analysis |
| spellingShingle | N. K. Mazina P. V. Mazin R. KH. Khafizyanova Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results Антибиотики и Химиотерапия tuberculosis (pulmonary form) meta-analysis odds ratio unified indicators of clinical efficacy outcomes frequency models of fixed and random effects heterogeneity and sensitivity analysis |
| title | Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results |
| title_full | Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results |
| title_fullStr | Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results |
| title_full_unstemmed | Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results |
| title_short | Clinical Efficacy of Cycloferon in The Complex Therapy of Tuberculosis: Systematic Review and Meta-Analysis Results |
| title_sort | clinical efficacy of cycloferon in the complex therapy of tuberculosis systematic review and meta analysis results |
| topic | tuberculosis (pulmonary form) meta-analysis odds ratio unified indicators of clinical efficacy outcomes frequency models of fixed and random effects heterogeneity and sensitivity analysis |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/125 |
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