Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study
Background: Managing patients with severe asthma with an eosinophilic phenotype (SEA) with comorbid respiratory conditions such as chronic rhinosinusitis with nasal polyps (CRSwNP) continues to encounter significant challenges and lack of coordinated management among treating physicians. Objective:...
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Elsevier
2025-11-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325001304 |
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| author | Claus Bachert, MD, PhD Guy Brusselle, MD, PhD José Antonio Castillo Vizuete, MD, PhD Ignacio Dávila, MD, PhD Martin Laudien, MD, PhD Veronica Seccia, MD, PhD Peter Schmid-Grendelmeier, MD, PhD Alessandra Vultaggio, MD, PhD Konstantina Kallinikou, PhD Laura Walrave, PhD Ludger Klimek, MD, PhD |
| author_facet | Claus Bachert, MD, PhD Guy Brusselle, MD, PhD José Antonio Castillo Vizuete, MD, PhD Ignacio Dávila, MD, PhD Martin Laudien, MD, PhD Veronica Seccia, MD, PhD Peter Schmid-Grendelmeier, MD, PhD Alessandra Vultaggio, MD, PhD Konstantina Kallinikou, PhD Laura Walrave, PhD Ludger Klimek, MD, PhD |
| author_sort | Claus Bachert, MD, PhD |
| collection | DOAJ |
| description | Background: Managing patients with severe asthma with an eosinophilic phenotype (SEA) with comorbid respiratory conditions such as chronic rhinosinusitis with nasal polyps (CRSwNP) continues to encounter significant challenges and lack of coordinated management among treating physicians. Objective: The OverSEA study aims to provide insights into current clinical practices and formulate recommendations for managing these patients. Methods: The two-round Delphi survey, conducted March-June 2023, was developed by a multidisciplinary 11-member Scientific Committee including pulmonologists, allergists, and ear, nose and throat specialists, and involved 205 experts from these specialties across 8 European countries. Consensus was defined as ≥70% agreement. Topics covered included the initial assessment, treatment, follow-up, and multidisciplinary management of patients with SEA and CRSwNP. Results: There was a consensus that evaluating for CRSwNP (88%), allergic rhinitis (79%), chronic rhinosinusitis without nasal polyps (77%), and aspirin/nonsteroidal anti-inflammatory-exacerbated respiratory disease (71%) is crucial for diagnosing upper respiratory tract comorbidities in patients with SEA. The necessity of a multidisciplinary approach for all stages of disease management (diagnosis, 82%; treatment decision-making, 83%, follow-up, 79%), and the usefulness of biologics in simultaneously managing asthma and CRSwNP symptoms (87%) were emphasized. Conclusion: The OverSEA study is the largest European initiative providing recommendations for optimizing the management of patients with SEA and comorbid CRSwNP. It underscores the importance of evaluating patients with SEA for comorbid upper airways diseases, particularly CRSwNP, and promotes a multidisciplinary approach, encouraging pulmonologists, allergists, and otorhinolaryngologists to collaborate closely to streamline patient diagnosis, follow-up, and treatment decisions. |
| format | Article |
| id | doaj-art-6d900e69a10d4d5fa01585f0b72e99a7 |
| institution | Kabale University |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
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| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-6d900e69a10d4d5fa01585f0b72e99a72025-08-20T03:41:56ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-11-014410052910.1016/j.jacig.2025.100529Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi studyClaus Bachert, MD, PhD0Guy Brusselle, MD, PhD1José Antonio Castillo Vizuete, MD, PhD2Ignacio Dávila, MD, PhD3Martin Laudien, MD, PhD4Veronica Seccia, MD, PhD5Peter Schmid-Grendelmeier, MD, PhD6Alessandra Vultaggio, MD, PhD7Konstantina Kallinikou, PhD8Laura Walrave, PhD9Ludger Klimek, MD, PhD10Department of Otorhinolaryngology, Head and Neck Surgery and the German Center of Diseases of the Upper Airway, University Hospital Münster, Münster, and the Department of Otorhinolaryngology, First Affiliated Hospital of Sun Yat-sen University, International Airway Research Center, Guangzhou, China; Corresponding author: Claus Bachert, MD, PhD, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Münster, Kardinal-Von-Galen-Ring 10, 48149 Muenster, Germany.Department of Respiratory Medicine, Ghent University Hospital, Ghent, BelgiumDepartment of Pulmonology, Hospital Universitari Dexeus, and the Group of Rhinitis, Rhinosinusitis and Nasal Polyps, Area of Asthma, SEPAR, Barcelona, SpainAllergy Service, University Hospital of Salamanca, Biomedical and Diagnosis Science Department, Salamanca University School of Medicine, Salamanca, SpainDepartment of Otorhinolaryngology, Head and Neck Surgery, Kiel University, University Medical Centre Schleswig-Holstein, Kiel, GermanyOtolaryngology Audiology and Phoniatric Operative Unit, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, ItalyAllergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, SwitzerlandImmunoallergology Unit, Careggi University Hospital, Department of Experimental and Clinical Medicine, University of Florence, Florence, ItalyGSK, Medical Affairs, Athens, GreeceGSK, Medical Affairs, Wavre, BelgiumCenter for Rhinology and Allergy, Wiesbaden, GermanyBackground: Managing patients with severe asthma with an eosinophilic phenotype (SEA) with comorbid respiratory conditions such as chronic rhinosinusitis with nasal polyps (CRSwNP) continues to encounter significant challenges and lack of coordinated management among treating physicians. Objective: The OverSEA study aims to provide insights into current clinical practices and formulate recommendations for managing these patients. Methods: The two-round Delphi survey, conducted March-June 2023, was developed by a multidisciplinary 11-member Scientific Committee including pulmonologists, allergists, and ear, nose and throat specialists, and involved 205 experts from these specialties across 8 European countries. Consensus was defined as ≥70% agreement. Topics covered included the initial assessment, treatment, follow-up, and multidisciplinary management of patients with SEA and CRSwNP. Results: There was a consensus that evaluating for CRSwNP (88%), allergic rhinitis (79%), chronic rhinosinusitis without nasal polyps (77%), and aspirin/nonsteroidal anti-inflammatory-exacerbated respiratory disease (71%) is crucial for diagnosing upper respiratory tract comorbidities in patients with SEA. The necessity of a multidisciplinary approach for all stages of disease management (diagnosis, 82%; treatment decision-making, 83%, follow-up, 79%), and the usefulness of biologics in simultaneously managing asthma and CRSwNP symptoms (87%) were emphasized. Conclusion: The OverSEA study is the largest European initiative providing recommendations for optimizing the management of patients with SEA and comorbid CRSwNP. It underscores the importance of evaluating patients with SEA for comorbid upper airways diseases, particularly CRSwNP, and promotes a multidisciplinary approach, encouraging pulmonologists, allergists, and otorhinolaryngologists to collaborate closely to streamline patient diagnosis, follow-up, and treatment decisions.http://www.sciencedirect.com/science/article/pii/S2772829325001304Severe asthmatype 2 inflammationeosinophilic phenotypechronic rhinosinusitisnasal polypscomorbidities |
| spellingShingle | Claus Bachert, MD, PhD Guy Brusselle, MD, PhD José Antonio Castillo Vizuete, MD, PhD Ignacio Dávila, MD, PhD Martin Laudien, MD, PhD Veronica Seccia, MD, PhD Peter Schmid-Grendelmeier, MD, PhD Alessandra Vultaggio, MD, PhD Konstantina Kallinikou, PhD Laura Walrave, PhD Ludger Klimek, MD, PhD Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study Journal of Allergy and Clinical Immunology: Global Severe asthma type 2 inflammation eosinophilic phenotype chronic rhinosinusitis nasal polyps comorbidities |
| title | Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study |
| title_full | Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study |
| title_fullStr | Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study |
| title_full_unstemmed | Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study |
| title_short | Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study |
| title_sort | consensus from european experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps results from the oversea delphi study |
| topic | Severe asthma type 2 inflammation eosinophilic phenotype chronic rhinosinusitis nasal polyps comorbidities |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325001304 |
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