Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways
The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formati...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0021 |
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| author | Liu Rui Yu Runze Cui Yuxin Fan Mengying Wang Bo Zhang Yanmin |
| author_facet | Liu Rui Yu Runze Cui Yuxin Fan Mengying Wang Bo Zhang Yanmin |
| author_sort | Liu Rui |
| collection | DOAJ |
| description | The aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways. |
| format | Article |
| id | doaj-art-6d8e609617b9437e83002bf5c4eeae56 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-6d8e609617b9437e83002bf5c4eeae562025-02-02T17:46:44ZengSciendoActa Pharmaceutica1846-95582019-09-0169342343110.2478/acph-2019-0021acph-2019-0021Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathwaysLiu Rui0Yu Runze1Cui Yuxin2Fan Mengying3Wang Bo4Zhang Yanmin5School of Pharmacy, Xi’an Jiaotong University, 710061Xi’an, Shaanxi ChinaSchool of Pharmacy, Xi’an Jiaotong University, 710061Xi’an, Shaanxi ChinaSchool of Pharmacy, Xi’an Jiaotong University, 710061Xi’an, Shaanxi ChinaSchool of Pharmacy, Xi’an Jiaotong University, 710061Xi’an, Shaanxi ChinaSchool of Pharmacy, Xi’an Jiaotong University, 710061Xi’an, Shaanxi ChinaSchool of Pharmacy, Xi’an Jiaotong University, 710061Xi’an, Shaanxi ChinaThe aim of this study was to investigate the inhibitory effect of TAD1822-7, a synthesized taspine derivative, on cancer through its effects on tumor cell growth and angiogenesis via suppression of EphrinB2. The obtained data showed that TAD1822-7 decreased Bel-7402 cell viability and colony formation ability and suppressed cell migration. TAD1822-7 effectively inhibited blood vessel formation in an aortic ring assay to examine angiogenesis. Moreover, it also down regulated the expression of VEGFR2, VEGFR3, CD34, PLCγ, Akt, MMP2, MMP9, and CXCR4, and suppressed the expression of EphrinB2 and its PDZ protein, PICK1, in Bel-7402 cells. These results indicate that TAD1822-7 is a potential anti-angiogenic agent that can inhibit the viability and migration of Bel-7402 cells via suppression of EphrinB2 and the related signaling pathways.https://doi.org/10.2478/acph-2019-0021tad1822-7ephrinb2bel-7402 cellsproliferationmigrationanti-angiogenesis |
| spellingShingle | Liu Rui Yu Runze Cui Yuxin Fan Mengying Wang Bo Zhang Yanmin Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways Acta Pharmaceutica tad1822-7 ephrinb2 bel-7402 cells proliferation migration anti-angiogenesis |
| title | Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways |
| title_full | Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways |
| title_fullStr | Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways |
| title_full_unstemmed | Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways |
| title_short | Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways |
| title_sort | inhibitory effect of taspine derivative tad1822 7 on tumor cell growth and angiogenesis via suppression of ephrinb2 and related signaling pathways |
| topic | tad1822-7 ephrinb2 bel-7402 cells proliferation migration anti-angiogenesis |
| url | https://doi.org/10.2478/acph-2019-0021 |
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