Bedaquiline and linezolid regimens for multidrug-resistant tuberculosis: a systematic review and meta-analysis

Bedaquiline and linezolid regimens for multidrug-resistant tuberculosis: a systematic review and meta-analysis

ABSTRACT Objective: Multidrug-resistant tuberculosis (MDR-TB) remains a global public health challenge, complicating treatment strategies and requiring advanced therapeutic approaches. The persistence of MDR-TB has led to a demand for regimens that are more effective in improving treatment outcomes...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mahdis Cheraghi, Mehrnaz Amiri, Sahar Andarzgoo, Fatemeh Zarei, Zahra Sadat Seghatoleslami, Rosella Centis, Dina Visca, Lia D’Ambrosio, Emanuele Pontali, Mohammad Javad Nasiri, Giovanni Battista Migliori
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Pneumologia e Tisiologia 2025-03-01
Series:	Jornal Brasileiro de Pneumologia
Subjects:	Linezolid Tuberculosis Tuberculosis, multidrug-resistant Treatment outcome Systematic review
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132025000101500&lng=en&tlng=en
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM) for multidrug- or rifampin-resistant tuberculosis: a systematic review
by: Denise Rossato Silva, et al.
Published: (2025-01-01)

Occurrence and predictors of adverse events associated with linezolid in the treatment of patients with drug resistant tuberculosis and their impact on treatment outcomes
by: Abhirami V, et al.
Published: (2025-06-01)

Post-tuberculosis lung disease patients benefit from vaccinations as other respiratory conditions
by: Giovanni Battista Migliori, et al.
Published: (2025-05-01)

Distribution of Minimum Inhibitory Concentrations and Resistance-associated Gene Mutations in Multidrug-resistant Mycobacterium tuberculosis Strains from Southern Türkiye: Insights on Bedaquiline, Delamanid, and Linezolid
by: Huda Ahmed, et al.
Published: (2024-12-01)

Adverse effects of linezolid in the treatment of drug-resistant tuberculosis combined with diabetic peripheral neuropathy
by: Yanjun Li, et al.
Published: (2025-08-01)

Safety and Tolerability of Contezolid Versus Linezolid for Short-Term Treatment of Rifampicin-Resistant Pulmonary Tuberculosis: A Randomized Controlled Study
by: Wang J, et al.
Published: (2025-07-01)

Risk of tuberculosis disease in patients receiving TNF-α antagonist therapy: A meta-analysis of randomized controlled trials
by: Fatemeh Khelghati, et al.
Published: (2024-12-01)

EXPERIENCE OF USING BEDAQUILINE AND LINEZOLID IN THE INTEGRAL TREATMENT OF THE PULMONARY TUBERCULOSIS PATIENT WITH EXTENSIVE DRUG RESISTANCE OF M. TUBERCULOSIS
by: E. M. Zhukova, et al.
Published: (2016-10-01)

Hepatic safety of pretomanid- and pyrazinamide-containing regimens in TB Alliance clinical trials
by: J. Nedelman, et al.
Published: (2025-08-01)

Effectiveness of a bedaquiline, linezolid, clofazimine ‘core’ for multidrug-resistant TB
by: C. Zeng, et al.
Published: (2025-05-01)

TB financing in East Europe promotes unnecessary hospital admissions: the case of Armenia
by: Laura Gillini, et al.
Published: (2013-03-01)

Case Report: Linezolid-associated toxic optic neuropathy in patients with pulmonary tuberculosis: case series and mini review
by: Hee Jin Yun, et al.
Published: (2025-05-01)

Risk factors for linezolid-associated thrombocytopenia and negative effect of carbapenem combination
by: Esra Kaya Kılıç, et al.
Published: (2019-10-01)

Linezolid-induced haematological toxicity
by: Libe Moraza, et al.
Published: (2015-11-01)

Investigation of delamanid, bedaquiline, and linezolid resistance rates and related gene mutations in multidrug-resistant Mycobacterium tuberculosis in regional tuberculosis reference laboratories of Iran
by: Nazanin Ahmad Khosravi, et al.
Published: (2025-08-01)

Association of clinical factors with thrombocytopenia in patients receiving linezolid treatment: a retrospective study
by: Le Thi Phuong Thao, et al.
Published: (2024-02-01)

The study of cross-resistance of MTB to certain anti-tuberculosis drugs among tuberculosis patients in Tomsk Region
by: P. N. Golubchikov, et al.
Published: (2020-01-01)

THE EFFECT OF DIFFERENT TB DRUGS AND ANTIMICROBIAL AGENTS ON THE EFFICIENCY OF TREATMENT OF TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE
by: I. A. Vasilyeva, et al.
Published: (2017-11-01)

Inhalation Surfactant Therapy within Comprehensive Treatment of HIV-Infected Patients with Multiple Drug Resistant Tuberculosis
by: E. M. Zhukova, et al.
Published: (2023-10-01)

TB survivors: why curing TB is sometimes not enough
by: E. Pontali, et al.
Published: (2024-12-01)

Using Machine Learning to Predict Linezolid-Associated Thrombocytopenia
by: Wei R, et al.
Published: (2025-05-01)

ACTG A5409 (RAD-TB): Study protocol for a phase 2 randomized, adaptive, dose-ranging, open-label trial of novel regimens for the treatment of pulmonary tuberculosis
by: Linda J. Harrison, et al.
Published: (2025-08-01)

Diagnostic accuracy of direct drug susceptibility testing of second-line antitubercular drugs
by: Kartiki Srivastava, et al.
Published: (2025-05-01)

Cost-effectiveness of bedaquiline in MDR and XDR tuberculosis in Italy
by: Luigi R. Codecasa, et al.
Published: (2017-01-01)

STUDY OF ADVERSE DRUG REACTIONS OF LINEZOLID IN DRUG RESISTANT TUBERCULOSIS PATIENTS
by: Rinto Susilo, et al.
Published: (2025-06-01)

Comparative analysis of eﬃcacy and safety of various anti-tuberculosis therapy regimens in patients with MDR/XDR tuberculosis
by: E. P. Myshkova, et al.
Published: (2022-06-01)

Experience of using bedaquiline in the treatment of pulmonary tuberculosis patients with multiple drug resistance
by: T. I. Morozova, et al.
Published: (2016-02-01)

Risk factors for linezolid - induced haematological toxicity in patients: a retrospective study
by: Kai Mo, et al.
Published: (2024-08-01)

Evaluation of a modified short all oral treatment regimen for rifampicin-multidrug resistant tuberculosis in Dominican Republic
by: María Rodríguez, et al.
Published: (2025-02-01)

Recent advancements in tuberculosis (TB) treatment regimens
by: Shyamala Ravikoti, et al.
Published: (2025-02-01)

Parameters of Complete Blood Count and Blood Chemistry during Treatment of Patients with MDR/XDR Pulmonary Tuberculosis with a Short-Course Regimen Containing Bedaquiline, Pretomanid, and Linezolid
by: R. Yu. Abdullaev, et al.
Published: (2023-08-01)

Concentration-Dependent Enrichment of Linezolid-Resistant Staphylococcus aureus in an in vitro Dynamic Model
by: K. N. Alieva, et al.
Published: (2020-05-01)

Children’s preferences among six novel moxifloxacin and linezolid-dispersible tablet formulations
by: G. Hoddinott, et al.
Published: (2025-04-01)

Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration
by: Graham Hagger, et al.
Published: (2024-12-01)

Efficacy and safety of chemotherapy regimens with bedaquiline in patients with respiratory tuberculosis: immediate and final results
by: S. E. Borisov, et al.
Published: (2019-05-01)

Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006–2022
by: Roxana Paul, et al.
Published: (2025-03-01)

COMPARISON OF THE CLINICAL ACTIVITY OF TWO OXAZOLIDINONES – LINEZOLID AND TEDIZOLIDE: UNJUSTIFIED EXPECTATIONS
by: N. V. Dmitrieva, et al.
Published: (2018-11-01)

Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China
by: Qun Wang, et al.
Published: (2025-08-01)

Enhanced efficacy of sequential administration of fosfomycin and linezolid against methicillin-resistant Staphylococcus aureus
by: Zaixing Chen, et al.
Published: (2025-03-01)

Clinical efficacy of linezolid in the treatment of tuberculous meningitis: a retrospective analysis and literature review
by: Zhen-Tao Fei, et al.
Published: (2025-04-01)