Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes
ObjectivesThis study aims to segment intra-tumoral subregions of breast cancer based on kinetic heterogeneity using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). It also aims to construct a radiomics model of the whole tumor and washout region to predict molecular subtypes and huma...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1635296/full |
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| author | Yue Cheng Ran Ren Yu Xu Shaofeng Duan Jilei Zhang Zhongyuan Bao |
| author_facet | Yue Cheng Ran Ren Yu Xu Shaofeng Duan Jilei Zhang Zhongyuan Bao |
| author_sort | Yue Cheng |
| collection | DOAJ |
| description | ObjectivesThis study aims to segment intra-tumoral subregions of breast cancer based on kinetic heterogeneity using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). It also aims to construct a radiomics model of the whole tumor and washout region to predict molecular subtypes and human epidermal growth factor receptor 2 (HER2) status.MethodsA total of 124 patients with biopsy-confirmed breast cancer were randomly divided into training and test sets in a 7:3 ratio. Quantitative analysis of breast cancer kinetic heterogeneity parameters based on DCE-MRI data was performed, dividing tumors into three subregions (Persistent, Washout, and Plateau) according to the type of voxel-level contrast enhancement. Radiomics features of the washout region and the whole tumor were extracted from the first phase of DCE-MRI enhancement. The area under the receiver operating characteristic curve (AUC) and decision curve analysis (DCA) were used to evaluate the performance of the model.ResultsThe radiomics model using tumor subregion (washout region) features related to kinetic heterogeneity showed the best performance for differentiating between patients with Luminal, HER2, and HER2 status, with AUC values in the train set of 0.924, 0.876, and 0.816, respectively. Exhibiting an AUC value higher than that obtained with the whole tumor and the kinetic heterogeneity parameters. DCA curves showed that the washout region model was more effective in predicting Luminal and HER2-status subtypes, compared to the whole tumor region model.ConclusionRadiomics analysis of washout areas from high-resolution DCE-MRI breast scans has the potential to better identify molecular subtypes of breast cancer non-invasively. |
| format | Article |
| id | doaj-art-6d863f0e538246ebbb59b7e3af91fe36 |
| institution | DOAJ |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-6d863f0e538246ebbb59b7e3af91fe362025-08-20T03:12:09ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-07-011210.3389/fmolb.2025.16352961635296Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypesYue Cheng0Ran Ren1Yu Xu2Shaofeng Duan3Jilei Zhang4Zhongyuan Bao5Department of Radiology, Wuxi No. 2 People’s Hospital, Jiangnan University Medical Center, Wuxi, ChinaDepartment of Radiology, Wuxi No. 2 People’s Hospital, Jiangnan University Medical Center, Wuxi, ChinaDepartment of Radiology, Wuxi Branch of Zhongda Hospital Southeast University, Wuxi, ChinaGE Healthcare, Precision Health Institution, Shanghai, ChinaBayer Healthcare, Shanghai, ChinaDepartment of Neurosurgery, Wuxi Institute of Neurosurgery, Wuxi, ChinaObjectivesThis study aims to segment intra-tumoral subregions of breast cancer based on kinetic heterogeneity using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). It also aims to construct a radiomics model of the whole tumor and washout region to predict molecular subtypes and human epidermal growth factor receptor 2 (HER2) status.MethodsA total of 124 patients with biopsy-confirmed breast cancer were randomly divided into training and test sets in a 7:3 ratio. Quantitative analysis of breast cancer kinetic heterogeneity parameters based on DCE-MRI data was performed, dividing tumors into three subregions (Persistent, Washout, and Plateau) according to the type of voxel-level contrast enhancement. Radiomics features of the washout region and the whole tumor were extracted from the first phase of DCE-MRI enhancement. The area under the receiver operating characteristic curve (AUC) and decision curve analysis (DCA) were used to evaluate the performance of the model.ResultsThe radiomics model using tumor subregion (washout region) features related to kinetic heterogeneity showed the best performance for differentiating between patients with Luminal, HER2, and HER2 status, with AUC values in the train set of 0.924, 0.876, and 0.816, respectively. Exhibiting an AUC value higher than that obtained with the whole tumor and the kinetic heterogeneity parameters. DCA curves showed that the washout region model was more effective in predicting Luminal and HER2-status subtypes, compared to the whole tumor region model.ConclusionRadiomics analysis of washout areas from high-resolution DCE-MRI breast scans has the potential to better identify molecular subtypes of breast cancer non-invasively.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1635296/fullbreast cancersubregionskinetic heterogeneityradiomicsdynamic contrast-enhanced magnetic resonance imaging |
| spellingShingle | Yue Cheng Ran Ren Yu Xu Shaofeng Duan Jilei Zhang Zhongyuan Bao Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes Frontiers in Molecular Biosciences breast cancer subregions kinetic heterogeneity radiomics dynamic contrast-enhanced magnetic resonance imaging |
| title | Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes |
| title_full | Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes |
| title_fullStr | Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes |
| title_full_unstemmed | Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes |
| title_short | Dynamic contrast-enhanced MRI-based radiomics model of intra-tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes |
| title_sort | dynamic contrast enhanced mri based radiomics model of intra tumoral kinetic heterogeneity for predicting breast cancer molecular subtypes |
| topic | breast cancer subregions kinetic heterogeneity radiomics dynamic contrast-enhanced magnetic resonance imaging |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1635296/full |
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