Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma
Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic e...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Istanbul University Press
2024-03-01
|
| Series: | The Turkish Journal of Ear Nose and Throat |
| Subjects: | |
| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/4956D8CE4C8442F9A3623CAE20417460 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849323880508817408 |
|---|---|
| author | Saber Chebouki Zeynep Nil Ünal Kemal Koray Bal Harun Gür Onur İsmi Murat Ünal |
| author_facet | Saber Chebouki Zeynep Nil Ünal Kemal Koray Bal Harun Gür Onur İsmi Murat Ünal |
| author_sort | Saber Chebouki |
| collection | DOAJ |
| description | Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer.Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study.Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups.Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker. |
| format | Article |
| id | doaj-art-6d7fcbec426e44dabea614142bdd00b2 |
| institution | Kabale University |
| issn | 2602-4837 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | The Turkish Journal of Ear Nose and Throat |
| spelling | doaj-art-6d7fcbec426e44dabea614142bdd00b22025-08-20T03:48:52ZengIstanbul University PressThe Turkish Journal of Ear Nose and Throat2602-48372024-03-013411710.26650/Tr-ENT.2024.1402917123456Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell CarcinomaSaber Chebouki0https://orcid.org/0000-0003-0768-8728Zeynep Nil Ünal1https://orcid.org/0000-0002-4083-0944Kemal Koray Bal2Harun Gür3https://orcid.org/0000-0001-6165-2350Onur İsmi4https://orcid.org/0000-0001-5061-8907Murat Ünal5https://orcid.org/0000-0002-5524-9175Mersin Üniversitesi, Mersin, TurkiyeMersin Üniversitesi, Mersin, TurkiyeMersin Üniversitesi, Mersin, TurkiyeMersin Üniversitesi, Mersin, TurkiyeMersin Üniversitesi, Mersin, TurkiyeMersin Üniversitesi, Mersin, TurkiyeObjective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer.Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study.Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups.Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/4956D8CE4C8442F9A3623CAE20417460vitamin dgenesneoplasmscalciumphosphorusreal-time polymerase chain reaction |
| spellingShingle | Saber Chebouki Zeynep Nil Ünal Kemal Koray Bal Harun Gür Onur İsmi Murat Ünal Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma The Turkish Journal of Ear Nose and Throat vitamin d genes neoplasms calcium phosphorus real-time polymerase chain reaction |
| title | Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma |
| title_full | Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma |
| title_short | Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma |
| title_sort | evaluation of the relationship between vitamin d receptor gene polymorphism and head and neck squamous cell carcinoma |
| topic | vitamin d genes neoplasms calcium phosphorus real-time polymerase chain reaction |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/4956D8CE4C8442F9A3623CAE20417460 |
| work_keys_str_mv | AT saberchebouki evaluationoftherelationshipbetweenvitamindreceptorgenepolymorphismandheadandnecksquamouscellcarcinoma AT zeynepnilunal evaluationoftherelationshipbetweenvitamindreceptorgenepolymorphismandheadandnecksquamouscellcarcinoma AT kemalkoraybal evaluationoftherelationshipbetweenvitamindreceptorgenepolymorphismandheadandnecksquamouscellcarcinoma AT harungur evaluationoftherelationshipbetweenvitamindreceptorgenepolymorphismandheadandnecksquamouscellcarcinoma AT onurismi evaluationoftherelationshipbetweenvitamindreceptorgenepolymorphismandheadandnecksquamouscellcarcinoma AT muratunal evaluationoftherelationshipbetweenvitamindreceptorgenepolymorphismandheadandnecksquamouscellcarcinoma |