Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka
Childhood obesity-related metabolic derangements are increasing among South Asian populations. Most of these changes persist to adulthood. This study aims to describe the distribution of metabolic abnormalities among 7- to 17-year-old overweight and obese children in the Gampaha District of Sri Lank...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/9936889 |
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| author | Loretta S. Warnakulasuriya Dulani L. Samaranayake Adikaram V. N. Adikaram Manel M. A. Fernando Elisabet Rytter Iris Ciba Peter Bergsten Anders H. Forslund K. D. Renuka Ruchira Silva Vithanage Pujitha Wickramasinghe |
| author_facet | Loretta S. Warnakulasuriya Dulani L. Samaranayake Adikaram V. N. Adikaram Manel M. A. Fernando Elisabet Rytter Iris Ciba Peter Bergsten Anders H. Forslund K. D. Renuka Ruchira Silva Vithanage Pujitha Wickramasinghe |
| author_sort | Loretta S. Warnakulasuriya |
| collection | DOAJ |
| description | Childhood obesity-related metabolic derangements are increasing among South Asian populations. Most of these changes persist to adulthood. This study aims to describe the distribution of metabolic abnormalities among 7- to 17-year-old overweight and obese children in the Gampaha District of Sri Lanka. Overweight children (age- and gender-adapted BMI>+1SD, WHO standards) were selected from a community survey carried out in the Negombo Education Zone of Gampaha District. After a 12-hour overnight fast, blood was drawn, and blood glucose (FBG), lipid profile, insulin, and liver transaminases were measured. Two hours after a glucose load, blood was drawn for random blood glucose (RBG) and insulin. Metabolic syndrome (MetS) was diagnosed using modified IDF criteria for children. Anthropometry, fat mass (FM), and blood pressure were measured. Hepatic fat pattern was assessed ultrasonically. The data of 403 children (210 boys) were analysed. Of the study population, 16.4% were overweight (BMI for age +1 to +2SD), 72% were obese (BMI for age >+2 to +3SD), and 11.6% were severely obese (BMI for age >+3SD). Insulin resistance was seen in 46.8%, and prevalence increased with age. Mean postprandial insulin ranged from 368 to 625 pmol/L and was elevated in 35%. Dysglycaemia was seen among 20.8%. MetS was present in 19.8%, and 84% had at least one metabolic abnormality. Different degrees of hepatic steatosis were observed in 32.5%, and elevated ALT/AST ratio was seen in 58% of the population. Overweight and obesity during childhood were associated with multiple metabolic abnormalities including MetS, and they occur from a young age. It is important to screen children for overweight/obesity early in life and intervene to prevent them from developing metabolic complications. |
| format | Article |
| id | doaj-art-6d7ca8b99f76498e8990bcace4403edf |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-6d7ca8b99f76498e8990bcace4403edf2025-08-20T03:33:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/99368899936889Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri LankaLoretta S. Warnakulasuriya0Dulani L. Samaranayake1Adikaram V. N. Adikaram2Manel M. A. Fernando3Elisabet Rytter4Iris Ciba5Peter Bergsten6Anders H. Forslund7K. D. Renuka Ruchira Silva8Vithanage Pujitha Wickramasinghe9Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri LankaDepartment of Community Medicine, University of Colombo, Colombo, Sri LankaHealth Unit, Bandaranaike International Airport, Katunayake, Sri LankaColombo North Teaching Hospital, Ragama, Sri LankaClinical Nutrition and Metabolism, Department of Public Health and Caring Science, Faculty of Medicine, Uppsala University, Uppsala, SwedenDepartment of Women’s and Children’s Health, Uppsala University, Uppsala, SwedenDepartment of Women’s and Children’s Health, Uppsala University, Uppsala, SwedenDepartment of Women’s and Children’s Health, Uppsala University, Uppsala, SwedenDepartment of Applied Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri LankaDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri LankaChildhood obesity-related metabolic derangements are increasing among South Asian populations. Most of these changes persist to adulthood. This study aims to describe the distribution of metabolic abnormalities among 7- to 17-year-old overweight and obese children in the Gampaha District of Sri Lanka. Overweight children (age- and gender-adapted BMI>+1SD, WHO standards) were selected from a community survey carried out in the Negombo Education Zone of Gampaha District. After a 12-hour overnight fast, blood was drawn, and blood glucose (FBG), lipid profile, insulin, and liver transaminases were measured. Two hours after a glucose load, blood was drawn for random blood glucose (RBG) and insulin. Metabolic syndrome (MetS) was diagnosed using modified IDF criteria for children. Anthropometry, fat mass (FM), and blood pressure were measured. Hepatic fat pattern was assessed ultrasonically. The data of 403 children (210 boys) were analysed. Of the study population, 16.4% were overweight (BMI for age +1 to +2SD), 72% were obese (BMI for age >+2 to +3SD), and 11.6% were severely obese (BMI for age >+3SD). Insulin resistance was seen in 46.8%, and prevalence increased with age. Mean postprandial insulin ranged from 368 to 625 pmol/L and was elevated in 35%. Dysglycaemia was seen among 20.8%. MetS was present in 19.8%, and 84% had at least one metabolic abnormality. Different degrees of hepatic steatosis were observed in 32.5%, and elevated ALT/AST ratio was seen in 58% of the population. Overweight and obesity during childhood were associated with multiple metabolic abnormalities including MetS, and they occur from a young age. It is important to screen children for overweight/obesity early in life and intervene to prevent them from developing metabolic complications.http://dx.doi.org/10.1155/2021/9936889 |
| spellingShingle | Loretta S. Warnakulasuriya Dulani L. Samaranayake Adikaram V. N. Adikaram Manel M. A. Fernando Elisabet Rytter Iris Ciba Peter Bergsten Anders H. Forslund K. D. Renuka Ruchira Silva Vithanage Pujitha Wickramasinghe Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka International Journal of Endocrinology |
| title | Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka |
| title_full | Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka |
| title_fullStr | Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka |
| title_full_unstemmed | Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka |
| title_short | Metabolic Abnormalities in a Cohort of Overweight and Obese Children in an Urban Setting of Sri Lanka |
| title_sort | metabolic abnormalities in a cohort of overweight and obese children in an urban setting of sri lanka |
| url | http://dx.doi.org/10.1155/2021/9936889 |
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