THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
Evolution of existing paradigms on regenerative capacity of the central nervous system (CNS) and eventual role of immune cells in restoration of damaged nervous tissue offers new prospectives in treatment of neurological disorders based on immunotherapeutic approaches. Present review article address...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2017-01-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/1158 |
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| author | E. R. Chernykh E. Ya. Shevela A. A. Ostanin |
| author_facet | E. R. Chernykh E. Ya. Shevela A. A. Ostanin |
| author_sort | E. R. Chernykh |
| collection | DOAJ |
| description | Evolution of existing paradigms on regenerative capacity of the central nervous system (CNS) and eventual role of immune cells in restoration of damaged nervous tissue offers new prospectives in treatment of neurological disorders based on immunotherapeutic approaches. Present review article addresses a role of macrophages in restoration of damaged CNS and provides data on functional heterogeneity of resident tissue macrophages (microglia), and monocyte-derived macrophages. We discuss possible ways of monocyte recruitment to CNS, relationships between microglia and recruited macrophages, as well as M1/M2 balance in neurological conditions. Moreover, the review proposes an experimental rationale for macrophage engagement into the CNS damage reconstruction, and concerns the mechanisms of macrophage regenerative activity. In summary, the data presented here allow us to suggest macrophages as a novel therapeutic target for suppression of neuroinflammation and enhancement of reparative processes. The first steps in the field are encouraging, with respect to clinical application of monocytes/macrophages or M1→M2 switching technologies for treatment of the neurological disorders, thus presuming a need for further research in this direction. |
| format | Article |
| id | doaj-art-6d7c42c9e9874fb381016eeff0d533a9 |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2017-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-6d7c42c9e9874fb381016eeff0d533a92025-08-20T03:37:45ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2017-01-0119171810.15789/1563-0625-2017-1-7-18876THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERSE. R. Chernykh0E. Ya. Shevela1A. A. Ostanin2Research Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyResearch Institute of Fundamental and Clinical ImmunologyEvolution of existing paradigms on regenerative capacity of the central nervous system (CNS) and eventual role of immune cells in restoration of damaged nervous tissue offers new prospectives in treatment of neurological disorders based on immunotherapeutic approaches. Present review article addresses a role of macrophages in restoration of damaged CNS and provides data on functional heterogeneity of resident tissue macrophages (microglia), and monocyte-derived macrophages. We discuss possible ways of monocyte recruitment to CNS, relationships between microglia and recruited macrophages, as well as M1/M2 balance in neurological conditions. Moreover, the review proposes an experimental rationale for macrophage engagement into the CNS damage reconstruction, and concerns the mechanisms of macrophage regenerative activity. In summary, the data presented here allow us to suggest macrophages as a novel therapeutic target for suppression of neuroinflammation and enhancement of reparative processes. The first steps in the field are encouraging, with respect to clinical application of monocytes/macrophages or M1→M2 switching technologies for treatment of the neurological disorders, thus presuming a need for further research in this direction.https://www.mimmun.ru/mimmun/article/view/1158central nervous systemmacrophagesmicrogliamonocyte-derived macrophagesfunctional phenotypesneuroprotectionneuroregenerationangiogenesiscerebral palsystrokeregenerative immunotherapy |
| spellingShingle | E. R. Chernykh E. Ya. Shevela A. A. Ostanin THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS Медицинская иммунология central nervous system macrophages microglia monocyte-derived macrophages functional phenotypes neuroprotection neuroregeneration angiogenesis cerebral palsy stroke regenerative immunotherapy |
| title | THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS |
| title_full | THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS |
| title_fullStr | THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS |
| title_full_unstemmed | THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS |
| title_short | THE ROLE OF MACROPHAGES IN DAMAGE RECOVERY OF CENTRAL NERVOUS SYSTEM: NEW OPTIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS |
| title_sort | role of macrophages in damage recovery of central nervous system new options for treatment of neurological disorders |
| topic | central nervous system macrophages microglia monocyte-derived macrophages functional phenotypes neuroprotection neuroregeneration angiogenesis cerebral palsy stroke regenerative immunotherapy |
| url | https://www.mimmun.ru/mimmun/article/view/1158 |
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