Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution

Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution

Abstract Hematopoietic stem cells (HSC) with multilineage potential are critical for T cell reconstitution after allogeneic hematopoietic cell transplantation (allo-HCT). The Kitlo HSC subset is enriched for multipotential precursors, but their T cell potential remains poorly characterized. Using a...

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Main Authors: Harold K. Elias, Sneha Mitra, Marina B. da Silva, Adhithi Rajagopalan, Brianna Gipson, Nicole Lee, Anastasia I. Kousa, Mohamed A. E. Ali, Simon Grassmann, Rhoshini Raghuraman, Xiaoqun C. Zhang, Susan DeWolf, Melody Smith, Hana Andrlova, Kimon V. Argyropoulos, Roshan Sharma, Teng Fei, Joseph C. Sun, Cynthia E. Dunbar, Christopher Y. Park, Christina S. Leslie, Avinash Bhandoola, Michael G. Kharas, Marcel R. M. van den Brink
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61125-1
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