Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment
Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing its admission to leukemic cell. Besides high antitumor effect, L-asparaginase drugs have side and toxic effects, such...
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ABV-press
2023-09-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/845 |
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| author | T. T. Valiev |
| author_facet | T. T. Valiev |
| author_sort | T. T. Valiev |
| collection | DOAJ |
| description | Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing its admission to leukemic cell. Besides high antitumor effect, L-asparaginase drugs have side and toxic effects, such as hypersensitivity reactions, thrombosis, pancreatitis / pancreatic necrosis, and hepatotoxicity. For L-asparaginase safety profile improvement a technology of pegylation was lay down and PEG-aspargase drug produced. This drug has less toxic effects and recommended as first-line therapy of acute lymphoblastic leukemia. Drug monitoring for assessment the effectiveness and toxicity of L-asparaginase is optimal. Such therapy individualization helps for L-asparaginase dose finding and decrease frequency and severity of side effects. |
| format | Article |
| id | doaj-art-6d7a3634f8eb42feb2414159ff7c96e2 |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-6d7a3634f8eb42feb2414159ff7c96e22025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232023-09-0118313413910.17650/1818-8346-2023-18-3-134-139706Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatmentT. T. Valiev0Research Institute of Pediatric Oncology and Hematology, N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing its admission to leukemic cell. Besides high antitumor effect, L-asparaginase drugs have side and toxic effects, such as hypersensitivity reactions, thrombosis, pancreatitis / pancreatic necrosis, and hepatotoxicity. For L-asparaginase safety profile improvement a technology of pegylation was lay down and PEG-aspargase drug produced. This drug has less toxic effects and recommended as first-line therapy of acute lymphoblastic leukemia. Drug monitoring for assessment the effectiveness and toxicity of L-asparaginase is optimal. Such therapy individualization helps for L-asparaginase dose finding and decrease frequency and severity of side effects.https://oncohematology.abvpress.ru/ongm/article/view/845l-asparaginasepeg-asparaginasetoxicityacute lymphoblastic leukemia |
| spellingShingle | T. T. Valiev Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment Онкогематология l-asparaginase peg-asparaginase toxicity acute lymphoblastic leukemia |
| title | Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment |
| title_full | Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment |
| title_fullStr | Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment |
| title_full_unstemmed | Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment |
| title_short | Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment |
| title_sort | toxicity of l asparaginase drugs in acute lymphoblastic leukemia treatment |
| topic | l-asparaginase peg-asparaginase toxicity acute lymphoblastic leukemia |
| url | https://oncohematology.abvpress.ru/ongm/article/view/845 |
| work_keys_str_mv | AT ttvaliev toxicityoflasparaginasedrugsinacutelymphoblasticleukemiatreatment |