Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue
Obesity is a chronic disease caused by the long-term interaction of multiple environmental factors on a specific genetic background. Among these factors， the overactivation of mineralocorticoid receptors （MR） plays a significant role in adipose tissue remodeling in obesity. In the obese state， the M...
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Editorial Office of Journal of New Medicine
2025-06-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1751417524508-1021187569.pdf |
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| author | WEN Runzhi, WANG Li, ZHAO Naiqian |
| author_facet | WEN Runzhi, WANG Li, ZHAO Naiqian |
| author_sort | WEN Runzhi, WANG Li, ZHAO Naiqian |
| collection | DOAJ |
| description | Obesity is a chronic disease caused by the long-term interaction of multiple environmental factors on a specific genetic background. Among these factors， the overactivation of mineralocorticoid receptors （MR） plays a significant role in adipose tissue remodeling in obesity. In the obese state， the MR overactivation in adipose tissue can promote adipose tissue differentiation and adipogenesis， and induce adipose tissue inflammation， oxidative stress， adipokine secretion disorders， and insulin resistance. These mechanisms contribute to adipose tissue remodeling in obesity， which is a key determinant of obesity-related metabolic diseases. Moreover， the use of MR antagonists can partially reverse the adipose tissue remodeling in obesity caused by MR overactivation. Therefore， it is of significant importance to clarify the role and mechanisms of MR overactivation in adipose tissue remodeling in obesity. |
| format | Article |
| id | doaj-art-6d766a90c8244204aec33c12219ddefd |
| institution | OA Journals |
| issn | 0253-9802 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj-art-6d766a90c8244204aec33c12219ddefd2025-08-20T02:37:32ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022025-06-0156662162610.12464/j.issn.0253-9802.2024-0431Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissueWEN Runzhi, WANG Li, ZHAO Naiqian01. The Second Clinical College of Medicine of Shanxi Medical University， Taiyuan 030001， China;2. Department of Geriatric， the Second Hospital of Shanxi Medical University， Taiyuan 030001， ChinaObesity is a chronic disease caused by the long-term interaction of multiple environmental factors on a specific genetic background. Among these factors， the overactivation of mineralocorticoid receptors （MR） plays a significant role in adipose tissue remodeling in obesity. In the obese state， the MR overactivation in adipose tissue can promote adipose tissue differentiation and adipogenesis， and induce adipose tissue inflammation， oxidative stress， adipokine secretion disorders， and insulin resistance. These mechanisms contribute to adipose tissue remodeling in obesity， which is a key determinant of obesity-related metabolic diseases. Moreover， the use of MR antagonists can partially reverse the adipose tissue remodeling in obesity caused by MR overactivation. Therefore， it is of significant importance to clarify the role and mechanisms of MR overactivation in adipose tissue remodeling in obesity.https://www.xinyixue.cn/fileup/0253-9802/PDF/1751417524508-1021187569.pdfobesity|mineralocorticoid receptor|mineralocorticoid receptor antagonist |
| spellingShingle | WEN Runzhi, WANG Li, ZHAO Naiqian Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue Xin yixue obesity|mineralocorticoid receptor|mineralocorticoid receptor antagonist |
| title | Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue |
| title_full | Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue |
| title_fullStr | Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue |
| title_full_unstemmed | Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue |
| title_short | Mineralocorticoid receptor overactivation-induced remodeling of obese adipose tissue |
| title_sort | mineralocorticoid receptor overactivation induced remodeling of obese adipose tissue |
| topic | obesity|mineralocorticoid receptor|mineralocorticoid receptor antagonist |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1751417524508-1021187569.pdf |
| work_keys_str_mv | AT wenrunzhiwanglizhaonaiqian mineralocorticoidreceptoroveractivationinducedremodelingofobeseadiposetissue |