Combination Treatment with Free Doxorubicin and Inductive Moderate Hyperthermia for Sarcoma Saos-2 Cells

Combination Treatment with Free Doxorubicin and Inductive Moderate Hyperthermia for Sarcoma Saos-2 Cells

<b>Background:</b> Osteosarcoma (OS) is the most common primary malignant bone tumor. Doxorubicin (DOX) is extensively used in OS chemotherapy, yet improving patient outcomes remains challenging. This study investigated the effect of free DOX combined with inductive moderate hyperthermia...

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Bibliographic Details
Main Authors: Valerii E. Orel, Anatolii G. Diedkov, Vasyl V. Ostafiichuk, Sergii A. Lyalkin, Igor O. Tkachenko, Denys L. Kolesnyk, Valerii B. Orel, Olga Yo. Dasyukevich, Oleksandr Yu. Rykhalskyi, Oleksii V. Movchan, Alexander Yu. Galkin, Anna B. Prosvietova
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
osteosarcoma
free doxorubicin
inductive moderate hyperthermia
antitumor effect
reactive oxygen species
p14<sup>ARF</sup>
Online Access:https://www.mdpi.com/1424-8247/18/6/852
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