Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems
Head and neck cancer (HNC) represents a heterogeneous group of malignancies with high global incidence and mortality rates. Traditional treatments for advanced HNC, such as combined radiotherapy and chemotherapy, often lead to debilitating long-term side effects that significantly affect patients qu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-11-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426825001915 |
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| author | Manoj Kumar Srinivasan Monisha Prasad |
| author_facet | Manoj Kumar Srinivasan Monisha Prasad |
| author_sort | Manoj Kumar Srinivasan |
| collection | DOAJ |
| description | Head and neck cancer (HNC) represents a heterogeneous group of malignancies with high global incidence and mortality rates. Traditional treatments for advanced HNC, such as combined radiotherapy and chemotherapy, often lead to debilitating long-term side effects that significantly affect patients quality of life. In response to these limitations, tumor-targeted polymer-based nanoparticles have emerged as a promising strategy to improve therapeutic efficacy while minimizing adverse effects. Polymeric nanoparticles comprised of natural or synthetic polymers and sized between 10 and 1000 nm have several benefits, including biocompatibility, adaptable drug release patterns, and the capacity to improve the solubility and stability of medicinal compounds. These nanoparticles can be engineered to target medications to tumor sites specifically, lowering systemic toxicity and enhancing treatment results. This review focuses on recent advances in the targeted therapy of HNC using polymeric nanoparticles such as chitosan, alginate, cyclodextrin, poly (lactic acid), poly (caprolactone), poly (ethylene glycol), dendrimers, and micelles. The emphasis is on their mechanisms, advantages, and potential to transform present HNC treatments. |
| format | Article |
| id | doaj-art-6d6c48010f9b480c91f6709ffb09d339 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-6d6c48010f9b480c91f6709ffb09d3392025-08-20T05:06:44ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682025-11-011561316133010.1016/j.jobcr.2025.08.012Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systemsManoj Kumar Srinivasan0Monisha Prasad1Molecular Biology Lab, Department of ENT, Saveetha Medical College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu, India; Corresponding author.Molecular Nutrition and Genomics Lab, Department of Community Medicine, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, IndiaHead and neck cancer (HNC) represents a heterogeneous group of malignancies with high global incidence and mortality rates. Traditional treatments for advanced HNC, such as combined radiotherapy and chemotherapy, often lead to debilitating long-term side effects that significantly affect patients quality of life. In response to these limitations, tumor-targeted polymer-based nanoparticles have emerged as a promising strategy to improve therapeutic efficacy while minimizing adverse effects. Polymeric nanoparticles comprised of natural or synthetic polymers and sized between 10 and 1000 nm have several benefits, including biocompatibility, adaptable drug release patterns, and the capacity to improve the solubility and stability of medicinal compounds. These nanoparticles can be engineered to target medications to tumor sites specifically, lowering systemic toxicity and enhancing treatment results. This review focuses on recent advances in the targeted therapy of HNC using polymeric nanoparticles such as chitosan, alginate, cyclodextrin, poly (lactic acid), poly (caprolactone), poly (ethylene glycol), dendrimers, and micelles. The emphasis is on their mechanisms, advantages, and potential to transform present HNC treatments.http://www.sciencedirect.com/science/article/pii/S2212426825001915Head and neck cancerPolymeric nanoparticlesChitosanCyclodextrinpoly(ethylene glycol) |
| spellingShingle | Manoj Kumar Srinivasan Monisha Prasad Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems Journal of Oral Biology and Craniofacial Research Head and neck cancer Polymeric nanoparticles Chitosan Cyclodextrin poly(ethylene glycol) |
| title | Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems |
| title_full | Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems |
| title_fullStr | Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems |
| title_full_unstemmed | Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems |
| title_short | Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems |
| title_sort | recent advances in tumor targeted polymeric nanoparticles for hnc treatment enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems |
| topic | Head and neck cancer Polymeric nanoparticles Chitosan Cyclodextrin poly(ethylene glycol) |
| url | http://www.sciencedirect.com/science/article/pii/S2212426825001915 |
| work_keys_str_mv | AT manojkumarsrinivasan recentadvancesintumortargetedpolymericnanoparticlesforhnctreatmentenhancingtherapeuticefficacyviaengineeredandbiocompatibledrugdeliverysystems AT monishaprasad recentadvancesintumortargetedpolymericnanoparticlesforhnctreatmentenhancingtherapeuticefficacyviaengineeredandbiocompatibledrugdeliverysystems |