Cardiac Tamponade in Catastrophic Adult-Onset Still Disease With Secondary Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome: A Clinical, Histopathologic, and Immunologic Profile
Catastrophic adult-onset Still disease (AOSD) is a severe form of AOSD with organ failure. We describe a 27-year-old healthy man who presented with recurrent fevers, a rash, a sore throat, and hepatomegaly, suggestive of AOSD. With worsening disease, he developed a large pericardial effusion with ta...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-08-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2024.0313 |
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| Summary: | Catastrophic adult-onset Still disease (AOSD) is a severe form of AOSD with organ failure. We describe a 27-year-old healthy man who presented with recurrent fevers, a rash, a sore throat, and hepatomegaly, suggestive of AOSD. With worsening disease, he developed a large pericardial effusion with tamponade, requiring a pericardial window. We detail the clinical features of AOSD along with the first description, to our knowledge, of the histopathology of the pericardial tissue and the cytokine analysis of the pericardial fluid. |
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| ISSN: | 2767-7664 |