Association between Bone Mineral Density and Severity of Chronic Kidney Disease
Objective. We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods. Cross-sectional data from 11050 participants ag...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8852690 |
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| author | Jin-Feng Huang Xuan-Qi Zheng Xiao-Lei Sun Xiao Zhou Jian Liu Yan Michael Li Xiang-Yang Wang Xiao-Lei Zhang Ai-Min Wu |
| author_facet | Jin-Feng Huang Xuan-Qi Zheng Xiao-Lei Sun Xiao Zhou Jian Liu Yan Michael Li Xiang-Yang Wang Xiao-Lei Zhang Ai-Min Wu |
| author_sort | Jin-Feng Huang |
| collection | DOAJ |
| description | Objective. We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods. Cross-sectional data from 11050 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Specifically, Pearson correlation was applied to analyze the relationship between BMD and estimated glomerular filtration rate (eGFR). General linear models (GLMs) were adjusted for potential confounders and used to analyze mean BMD, based on CKD and CKD stages. Results. FN BMD was positively correlated with the eGFR in the total and male CKD, but not in the female CKD population. LS BMD was not significantly associated with eGFR. After controlling for partial correlations, FN T-score was positively correlated with the eGFR in the total at-risk population. According to FN BMD, OP prevalence was positively associated with CKD stage. However, according to LS BMD, there was no significant association between OP and CKD stage. Conclusion. Our results may explain the higher prevalence of hip fracture, relative to that of the spine, among CKD patients and generate meaningful insights to guide care, prevention, and treatment regimens for CKD patients. However, the fact that this was a cross-sectional study may limit the possibility of drawing concrete conclusions. Nevertheless, these findings open up a new frontier for further studies to uncover the higher decrease of FN BMD compared to LS BMD among CKD cases. |
| format | Article |
| id | doaj-art-6d64a816d3da4d00a599bd3f5590f8ee |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6d64a816d3da4d00a599bd3f5590f8ee2025-08-20T03:33:52ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/88526908852690Association between Bone Mineral Density and Severity of Chronic Kidney DiseaseJin-Feng Huang0Xuan-Qi Zheng1Xiao-Lei Sun2Xiao Zhou3Jian Liu4Yan Michael Li5Xiang-Yang Wang6Xiao-Lei Zhang7Ai-Min Wu8Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartment of Orthopaedics, Tianjin Hospital, Tianjin, ChinaRuian Institute of Quality and Technical Supervision and Inspection, Wenzhou 325000, ChinaDepartment of Nephrology, Rui Jin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, ChinaDepartment of Neurosurgery and Oncology, University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY 14642, USADepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang 325027, ChinaObjective. We sought to evaluate the association between femoral neck (FN) and lumbar spine (LS) bone mineral densities (BMDs) with severity of chronic kidney disease (CKD) and prevalence of osteopenia or osteoporosis (OP) among the CKD group. Methods. Cross-sectional data from 11050 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) were analyzed. Specifically, Pearson correlation was applied to analyze the relationship between BMD and estimated glomerular filtration rate (eGFR). General linear models (GLMs) were adjusted for potential confounders and used to analyze mean BMD, based on CKD and CKD stages. Results. FN BMD was positively correlated with the eGFR in the total and male CKD, but not in the female CKD population. LS BMD was not significantly associated with eGFR. After controlling for partial correlations, FN T-score was positively correlated with the eGFR in the total at-risk population. According to FN BMD, OP prevalence was positively associated with CKD stage. However, according to LS BMD, there was no significant association between OP and CKD stage. Conclusion. Our results may explain the higher prevalence of hip fracture, relative to that of the spine, among CKD patients and generate meaningful insights to guide care, prevention, and treatment regimens for CKD patients. However, the fact that this was a cross-sectional study may limit the possibility of drawing concrete conclusions. Nevertheless, these findings open up a new frontier for further studies to uncover the higher decrease of FN BMD compared to LS BMD among CKD cases.http://dx.doi.org/10.1155/2020/8852690 |
| spellingShingle | Jin-Feng Huang Xuan-Qi Zheng Xiao-Lei Sun Xiao Zhou Jian Liu Yan Michael Li Xiang-Yang Wang Xiao-Lei Zhang Ai-Min Wu Association between Bone Mineral Density and Severity of Chronic Kidney Disease International Journal of Endocrinology |
| title | Association between Bone Mineral Density and Severity of Chronic Kidney Disease |
| title_full | Association between Bone Mineral Density and Severity of Chronic Kidney Disease |
| title_fullStr | Association between Bone Mineral Density and Severity of Chronic Kidney Disease |
| title_full_unstemmed | Association between Bone Mineral Density and Severity of Chronic Kidney Disease |
| title_short | Association between Bone Mineral Density and Severity of Chronic Kidney Disease |
| title_sort | association between bone mineral density and severity of chronic kidney disease |
| url | http://dx.doi.org/10.1155/2020/8852690 |
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