Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco
Plants from Morocco's Taza region are rich in bioactive compounds such as flavonoids and polyphenols, renowned for their health benefits and antioxidant properties. This study investigates the antioxidant potential of Sonchus oleraceus and Lobularia maritima (L.) Desv. Using 80 % methanolic mac...
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Elsevier
2025-03-01
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| Series: | Food Chemistry Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772753X25000280 |
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| author | Abdelmounaim Laabar Imad Kabach Sara El Asri Amr Kchikich Soufiane Drioua Ayoub El Hamri Moulay El Abbes Faouzi |
| author_facet | Abdelmounaim Laabar Imad Kabach Sara El Asri Amr Kchikich Soufiane Drioua Ayoub El Hamri Moulay El Abbes Faouzi |
| author_sort | Abdelmounaim Laabar |
| collection | DOAJ |
| description | Plants from Morocco's Taza region are rich in bioactive compounds such as flavonoids and polyphenols, renowned for their health benefits and antioxidant properties. This study investigates the antioxidant potential of Sonchus oleraceus and Lobularia maritima (L.) Desv. Using 80 % methanolic maceration, three extracts were prepared: Sonchus oleraceus leaves, Lobularia maritima (L.) Desv-leaves, and Lobularia maritima (L.) Desv-flowers. Antioxidant activity was evaluated through DPPH, FRAP, ABTS, and metal-chelating assays, while flavonoid and polyphenol content was quantified spectrophotometrically.Antidiabetic potential was assessed via inhibition of α-glucosidase and α-amylase, and antiglycation activity was analyzed by measuring protein thiol preservation and fructosamine levels. All extracts exhibited significant antioxidant activity, with high flavonoid and polyphenol levels underscoring their potential as natural antioxidants. They also demonstrated notable α-glucosidase and α-amylase inhibition, suggesting their ability to regulate glucose metabolism. Moreover, their antiglycation effects, marked by the prevention of advanced glycation end products and protein damage, highlight their potential in maintaining cellular integrity.These findings suggest that Sonchus oleraceus and Lobularia maritima extracts possess promising antioxidant, antidiabetic, and anti-inflammatory properties, paving the way for their therapeutic application in managing diabetes, oxidative stress, and related conditions. |
| format | Article |
| id | doaj-art-6d6417fb88674c5b8eb863828e8bacbf |
| institution | Kabale University |
| issn | 2772-753X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry Advances |
| spelling | doaj-art-6d6417fb88674c5b8eb863828e8bacbf2025-02-08T05:01:43ZengElsevierFood Chemistry Advances2772-753X2025-03-016100912Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, MoroccoAbdelmounaim Laabar0Imad Kabach1Sara El Asri2Amr Kchikich3Soufiane Drioua4Ayoub El Hamri5Moulay El Abbes Faouzi6Laboratory of Pharmacology and Toxicology, Biopharmaceutical and toxicological analysis research team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco; Corresponding author.Laboratory of Biochemistry and Molecular Genetics, Faculty of Sciences and Technologies of Tangier, BP 416, 90000 Tangier, MoroccoLaboratory of Biochemistry and Molecular Genetics, Faculty of Sciences and Technologies of Tangier, BP 416, 90000 Tangier, MoroccoDepartment of Biology, Abdelmalek Essaadi University, Tangier 93000, Morocco; Regional Center of Agricultural Research of Tangier, National Institute of Agricultural Research, Rabat 10090, MoroccoLaboratory of Analytical Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, MoroccoDepartment of Chemistry, Faculty of Sciences, Mohammed V University, Av. Ibn Battuta P.O. Box 1014, Rabat, MoroccoLaboratory of Pharmacology and Toxicology, Biopharmaceutical and toxicological analysis research team, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, MoroccoPlants from Morocco's Taza region are rich in bioactive compounds such as flavonoids and polyphenols, renowned for their health benefits and antioxidant properties. This study investigates the antioxidant potential of Sonchus oleraceus and Lobularia maritima (L.) Desv. Using 80 % methanolic maceration, three extracts were prepared: Sonchus oleraceus leaves, Lobularia maritima (L.) Desv-leaves, and Lobularia maritima (L.) Desv-flowers. Antioxidant activity was evaluated through DPPH, FRAP, ABTS, and metal-chelating assays, while flavonoid and polyphenol content was quantified spectrophotometrically.Antidiabetic potential was assessed via inhibition of α-glucosidase and α-amylase, and antiglycation activity was analyzed by measuring protein thiol preservation and fructosamine levels. All extracts exhibited significant antioxidant activity, with high flavonoid and polyphenol levels underscoring their potential as natural antioxidants. They also demonstrated notable α-glucosidase and α-amylase inhibition, suggesting their ability to regulate glucose metabolism. Moreover, their antiglycation effects, marked by the prevention of advanced glycation end products and protein damage, highlight their potential in maintaining cellular integrity.These findings suggest that Sonchus oleraceus and Lobularia maritima extracts possess promising antioxidant, antidiabetic, and anti-inflammatory properties, paving the way for their therapeutic application in managing diabetes, oxidative stress, and related conditions.http://www.sciencedirect.com/science/article/pii/S2772753X25000280AntidiabeticAntiglycationFructosamineSonchus oleraceusLobularia maritima (L.) Desv |
| spellingShingle | Abdelmounaim Laabar Imad Kabach Sara El Asri Amr Kchikich Soufiane Drioua Ayoub El Hamri Moulay El Abbes Faouzi Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco Food Chemistry Advances Antidiabetic Antiglycation Fructosamine Sonchus oleraceus Lobularia maritima (L.) Desv |
| title | Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco |
| title_full | Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco |
| title_fullStr | Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco |
| title_full_unstemmed | Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco |
| title_short | Investigation of antioxidant, antidiabetic, and antiglycation properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. extracts from Taza, Morocco |
| title_sort | investigation of antioxidant antidiabetic and antiglycation properties of sonchus oleraceus and lobularia maritima l desv extracts from taza morocco |
| topic | Antidiabetic Antiglycation Fructosamine Sonchus oleraceus Lobularia maritima (L.) Desv |
| url | http://www.sciencedirect.com/science/article/pii/S2772753X25000280 |
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