Theory to predict shear stress on cells in turbulent blood flow.
Shear stress on blood cells and platelets transported in a turbulent flow dictates the fate and biological activity of these cells. We present a theoretical link between energy dissipation in turbulent flows to the shear stress that cells experience and show that for the case of physiological turbul...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0105357 |
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| _version_ | 1850127110554779648 |
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| author | Khandakar Niaz Morshed David Bark Marcio Forleo Lakshmi Prasad Dasi |
| author_facet | Khandakar Niaz Morshed David Bark Marcio Forleo Lakshmi Prasad Dasi |
| author_sort | Khandakar Niaz Morshed |
| collection | DOAJ |
| description | Shear stress on blood cells and platelets transported in a turbulent flow dictates the fate and biological activity of these cells. We present a theoretical link between energy dissipation in turbulent flows to the shear stress that cells experience and show that for the case of physiological turbulent blood flow: (a) the Newtonian assumption is valid, (b) turbulent eddies are universal for the most complex of blood flow problems, and (c) shear stress distribution on turbulent blood flows is possibly universal. Further we resolve a long standing inconsistency in hemolysis between laminar and turbulent flow using the theoretical framework. This work demonstrates that energy dissipation as opposed to bulk shear stress in laminar or turbulent blood flow dictates local mechanical environment of blood cells and platelets universally. |
| format | Article |
| id | doaj-art-6d60dd5b8c3346f0aac2a494232ccd5a |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6d60dd5b8c3346f0aac2a494232ccd5a2025-08-20T02:33:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10535710.1371/journal.pone.0105357Theory to predict shear stress on cells in turbulent blood flow.Khandakar Niaz MorshedDavid BarkMarcio ForleoLakshmi Prasad DasiShear stress on blood cells and platelets transported in a turbulent flow dictates the fate and biological activity of these cells. We present a theoretical link between energy dissipation in turbulent flows to the shear stress that cells experience and show that for the case of physiological turbulent blood flow: (a) the Newtonian assumption is valid, (b) turbulent eddies are universal for the most complex of blood flow problems, and (c) shear stress distribution on turbulent blood flows is possibly universal. Further we resolve a long standing inconsistency in hemolysis between laminar and turbulent flow using the theoretical framework. This work demonstrates that energy dissipation as opposed to bulk shear stress in laminar or turbulent blood flow dictates local mechanical environment of blood cells and platelets universally.https://doi.org/10.1371/journal.pone.0105357 |
| spellingShingle | Khandakar Niaz Morshed David Bark Marcio Forleo Lakshmi Prasad Dasi Theory to predict shear stress on cells in turbulent blood flow. PLoS ONE |
| title | Theory to predict shear stress on cells in turbulent blood flow. |
| title_full | Theory to predict shear stress on cells in turbulent blood flow. |
| title_fullStr | Theory to predict shear stress on cells in turbulent blood flow. |
| title_full_unstemmed | Theory to predict shear stress on cells in turbulent blood flow. |
| title_short | Theory to predict shear stress on cells in turbulent blood flow. |
| title_sort | theory to predict shear stress on cells in turbulent blood flow |
| url | https://doi.org/10.1371/journal.pone.0105357 |
| work_keys_str_mv | AT khandakarniazmorshed theorytopredictshearstressoncellsinturbulentbloodflow AT davidbark theorytopredictshearstressoncellsinturbulentbloodflow AT marcioforleo theorytopredictshearstressoncellsinturbulentbloodflow AT lakshmiprasaddasi theorytopredictshearstressoncellsinturbulentbloodflow |