Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations
Clear cell odontogenic carcinoma (CCOC) is a low-grade malignant neoplasm that affects the jaws. We report an 18 cm massive case of mandibular CCOC in a 43-year-old female. The tumor was composed of nests and cords of round to polygonal monomorphic clear cells separated by prominent stromal hyaliniz...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2021/5558019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850221329701142528 |
|---|---|
| author | Adepitan A. Owosho Chukwubuzor Okwuosa Donald I. Obi Robinson O. Okiti Kurt F. Summersgill |
| author_facet | Adepitan A. Owosho Chukwubuzor Okwuosa Donald I. Obi Robinson O. Okiti Kurt F. Summersgill |
| author_sort | Adepitan A. Owosho |
| collection | DOAJ |
| description | Clear cell odontogenic carcinoma (CCOC) is a low-grade malignant neoplasm that affects the jaws. We report an 18 cm massive case of mandibular CCOC in a 43-year-old female. The tumor was composed of nests and cords of round to polygonal monomorphic clear cells separated by prominent stromal hyalinization. Immunohistochemically, the tumor cells showed focal cytokeratin 5/6 positivity and intracytoplasmic PAS-positive granules and were negative for S100 and after diastase treatment (PAS-D). Molecularly, this case was positive for EWSR1 rearrangement by FISH. The following should be included in the histopathological differential diagnosis: hyalinizing clear cell carcinoma of the salivary gland, clear cell variant of central mucoepidermoid carcinoma, clear cell variant of calcifying epithelial odontogenic tumor, and metastatic renal cell carcinoma. CCOC is a rare entity, with only 79 cases reported in the mandible. This case highlights the propensity for CCOC to exhibit invasiveness, destructive nature, and facial disfigurement if left untreated. |
| format | Article |
| id | doaj-art-6d5c2316360e4fd5ab9d09ef092268b6 |
| institution | OA Journals |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-6d5c2316360e4fd5ab9d09ef092268b62025-08-20T02:06:44ZengWileyCase Reports in Dentistry2090-64472090-64552021-01-01202110.1155/2021/55580195558019Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic ConsiderationsAdepitan A. Owosho0Chukwubuzor Okwuosa1Donald I. Obi2Robinson O. Okiti3Kurt F. Summersgill4Missouri School of Dentistry and Oral Health, A.T. Still University, Kirksville, Missouri, USAUniversity of Nigeria Teaching Hospital, Nsukka, Enugu, NigeriaUniversity of Nigeria Teaching Hospital, Nsukka, Enugu, NigeriaUniversity College Hospital, Ibadan, Oyo, NigeriaDepartment of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USAClear cell odontogenic carcinoma (CCOC) is a low-grade malignant neoplasm that affects the jaws. We report an 18 cm massive case of mandibular CCOC in a 43-year-old female. The tumor was composed of nests and cords of round to polygonal monomorphic clear cells separated by prominent stromal hyalinization. Immunohistochemically, the tumor cells showed focal cytokeratin 5/6 positivity and intracytoplasmic PAS-positive granules and were negative for S100 and after diastase treatment (PAS-D). Molecularly, this case was positive for EWSR1 rearrangement by FISH. The following should be included in the histopathological differential diagnosis: hyalinizing clear cell carcinoma of the salivary gland, clear cell variant of central mucoepidermoid carcinoma, clear cell variant of calcifying epithelial odontogenic tumor, and metastatic renal cell carcinoma. CCOC is a rare entity, with only 79 cases reported in the mandible. This case highlights the propensity for CCOC to exhibit invasiveness, destructive nature, and facial disfigurement if left untreated.http://dx.doi.org/10.1155/2021/5558019 |
| spellingShingle | Adepitan A. Owosho Chukwubuzor Okwuosa Donald I. Obi Robinson O. Okiti Kurt F. Summersgill Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations Case Reports in Dentistry |
| title | Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations |
| title_full | Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations |
| title_fullStr | Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations |
| title_full_unstemmed | Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations |
| title_short | Clear Cell Odontogenic Carcinoma of the Mandible Harboring EWSR1 Rearrangement: Report of a Massive Jaw Tumor and Review of Diagnostic Considerations |
| title_sort | clear cell odontogenic carcinoma of the mandible harboring ewsr1 rearrangement report of a massive jaw tumor and review of diagnostic considerations |
| url | http://dx.doi.org/10.1155/2021/5558019 |
| work_keys_str_mv | AT adepitanaowosho clearcellodontogeniccarcinomaofthemandibleharboringewsr1rearrangementreportofamassivejawtumorandreviewofdiagnosticconsiderations AT chukwubuzorokwuosa clearcellodontogeniccarcinomaofthemandibleharboringewsr1rearrangementreportofamassivejawtumorandreviewofdiagnosticconsiderations AT donaldiobi clearcellodontogeniccarcinomaofthemandibleharboringewsr1rearrangementreportofamassivejawtumorandreviewofdiagnosticconsiderations AT robinsonookiti clearcellodontogeniccarcinomaofthemandibleharboringewsr1rearrangementreportofamassivejawtumorandreviewofdiagnosticconsiderations AT kurtfsummersgill clearcellodontogeniccarcinomaofthemandibleharboringewsr1rearrangementreportofamassivejawtumorandreviewofdiagnosticconsiderations |