Ibetazol, a novel inhibitor of importin β1-mediated nuclear import

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import

Abstract Nucleocytoplasmatic transport plays an essential role in eukaryotic cell homeostasis and is mediated by karyopherins. Importin β1 (KPNB1) and its adaptor protein importin α1 (KPNA2) are the best-characterized karyopherins that effect nuclear import. Here, we identify a novel small-molecule...

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Main Authors: Thomas Vercruysse, Els Vanstreels, Maarten Jacquemyn, Sandro Boland, Amuri Kilonda, Sara Allasia, Ilse Vandecaetsbeek, Hugo Klaassen, Matthias Versele, Patrick Chaltin, Arnaud Marchand, Dirk Daelemans
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07237-8
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