Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta
Actuality. The correlation analysis between various indices of bone tissue condition was not previously carried out in patients with osteogenesis imperfecta. Aim. On purpose to determine differences and index correlations before and after intake of pamidronate systemic therapy in 13 patients with o...
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| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-04-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/42883/39284 |
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| author | V. V. Hryhorovskyi A. M. Zyma Yu. M. Guk S. Mahomedov O. G. Gayko T. A. Kintchaia-Polishchuk |
| author_facet | V. V. Hryhorovskyi A. M. Zyma Yu. M. Guk S. Mahomedov O. G. Gayko T. A. Kintchaia-Polishchuk |
| author_sort | V. V. Hryhorovskyi |
| collection | DOAJ |
| description | Actuality. The correlation analysis between various indices of bone tissue condition was not previously carried out in patients with osteogenesis imperfecta.
Aim. On purpose to determine differences and index correlations before and after intake of pamidronate systemic therapy in 13 patients with osteogenesis imperfecta indices of some methods including histomorphometric were studied.
Results. We found correlation parametres of biochemical indices, on one side and histomorphometric – on the other.
Conclusion. After systemic therapy mean parametres of «bone volume» in iliobiopsies increase, and «osteoid surface» and «osteoclast index per surface unit» in patients with osteogenesis imperfecta of I type – decrease, that one can regard as a tendency to improvement of the bone tissue structural-functional condition. |
| format | Article |
| id | doaj-art-6d4c5c56aa7b47ef9e6e65308b65b2ed |
| institution | DOAJ |
| issn | 2306-8027 2310-1237 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj-art-6d4c5c56aa7b47ef9e6e65308b65b2ed2025-08-20T03:18:04ZengZaporizhzhia State Medical and Pharmaceutical UniversityPatologìâ2306-80272310-12372015-04-011566410.14739/2310-1237.2015.1.42883Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfectaV. V. HryhorovskyiA. M. ZymaYu. M. GukS. MahomedovO. G. GaykoT. A. Kintchaia-PolishchukActuality. The correlation analysis between various indices of bone tissue condition was not previously carried out in patients with osteogenesis imperfecta. Aim. On purpose to determine differences and index correlations before and after intake of pamidronate systemic therapy in 13 patients with osteogenesis imperfecta indices of some methods including histomorphometric were studied. Results. We found correlation parametres of biochemical indices, on one side and histomorphometric – on the other. Conclusion. After systemic therapy mean parametres of «bone volume» in iliobiopsies increase, and «osteoid surface» and «osteoclast index per surface unit» in patients with osteogenesis imperfecta of I type – decrease, that one can regard as a tendency to improvement of the bone tissue structural-functional condition.http://pat.zsmu.edu.ua/article/view/42883/39284Osteogenesis ImperfectaDrug TherapyDensitometryBiochemistryPamidronate |
| spellingShingle | V. V. Hryhorovskyi A. M. Zyma Yu. M. Guk S. Mahomedov O. G. Gayko T. A. Kintchaia-Polishchuk Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta Patologìâ Osteogenesis Imperfecta Drug Therapy Densitometry Biochemistry Pamidronate |
| title | Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta |
| title_full | Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta |
| title_fullStr | Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta |
| title_full_unstemmed | Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta |
| title_short | Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta |
| title_sort | statistical characteristics and correlations of histomorphometric clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta |
| topic | Osteogenesis Imperfecta Drug Therapy Densitometry Biochemistry Pamidronate |
| url | http://pat.zsmu.edu.ua/article/view/42883/39284 |
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